Results 101 to 110 of about 35,927 (289)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

APPLICATION OF ACCOUNTING INFORMATION IN INFLUENCING THE FINANCIAL PERFORMANCE OF MICRO, SMALL, AND MEDIUM ENTERPRISES WITH FINANCIAL LITERACY AS A MODERATOR VARIABLE

Finansia
The low utilization of accounting information by MSEs actors in managing and controlling business finances has resulted in suboptimal financial performance of MSEs.
Budi Gautama Siregar, Aswadi Lubis, Zaki Zaini   +2 more
doaj   +1 more source

Single point Seshadri constants on rational surfaces [PDF]

, 2017
Motivated by a similar result of Dumnicki, K\"uronya, Maclean and Szemberg under a slightly stronger hypothesis, we exhibit irrational single-point Seshadri constants on a rational surface $X$ obtained by blowing up very general points of $\mathbb{P}^2_ ...
Hanumanthu, Krishna, Harbourne, Brian
core   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

PENGARUH PROGRAM SERTIFIKASI TANAH TERHADAP AKSES PERMODALAN BAGI USAHA MIKRO DAN KECIL STUDI KASUS PROGRAM SERTIFIKASI TAHUN 2008 DI KABUPATEN KULON PROGO

Jurnal Kawistara, 2013
This paper discusses influence of land certification program on Micro and Small Enterprises (MSEs) to access capital through the identification of factors that influence the decision of micro and small entrepreneurs (MSEs) in the use of Certificate of ...
Istikomah Istikomah
doaj   +1 more source

Inference under progressively type II right censored sampling for certain lifetime distributions [PDF]

, 2009
In this paper, estimation of the parameters of a certain family of two-parameter lifetime distributions based on progressively Type II right censored samples (including ordinary Type II right censoring) is studied.
Jones, MC, Wang, BX, Yu, K
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Peran Kelembagaan Usaha Mikro Dan Kecil (UMK) Terhadap Laju Pertumbuhan Ekonomi (LPE) Jawa Barat

Mimbar, 2014
Micro and Small Enterprises (MSEs) is a general term for business entities that qualify Micro and Small scale enterprises. MSEs can be viewed from various perspectives.
Ida Nurnida Relawan
doaj