Results 171 to 180 of about 37,578 (264)

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

A Defined-Area Bonding Approach for Microtensile Testing: A Reliable Alternative to Monoblock Sectioning for High-Hardness Restorative Materials. [PDF]

J Funct Biomater
Yamashita K, Kawamoto C, Toida Y, Kawano S, Hoshika S, Sano H, Tomokiyo A.   +6 more
europepmc   +1 more source

Implementing a behavioural intervention for paediatric type 1 diabetes: Key informant perspectives of multilevel barriers and facilitators

Diabetic Medicine, EarlyView.
Providers, healthcare leaders, adolescents and caregivers identified evidence of intervention effectiveness in lowering glycaemic levels as a key facilitator of implementing a type 1 diabetes behavioural intervention. Critical barriers to implementation include buy‐in among clinic leaders, resource availability within clinics and meeting families ...
Julia Price, Janet A. Deatrick, Geoffrey Curran, Chia‐Lun Yang, Alejandra Perez Ramirez, Courtney Thomas, Anne E. Kazak   +6 more
wiley   +1 more source

Combining bacteriophages and essential oils for the elimination of monophasic Salmonella Typhimurium and evaluation of phage persistence in poultry farm environments. [PDF]

Poult Sci
Gentile N, Montoro-Dasi L, Marco-Fuertes A, Marín-García PJ, Domingo-Calap P, Lorenzo-Rebenaque L, Marin C.   +6 more
europepmc   +1 more source

Endothelial Function Is Associated With Incident Diabetes Mellitus: The ELSA‐Brasil Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetes mellitus is associated with endothelial dysfunction, but the bidirectional nature of this relationship remains debated. We aimed to evaluate the association between microvascular endothelial function and incident diabetes in Brazilian adults and to assess potential effect modification by obesity status.
Karina P. M. P. Martins, Sandhi M. Barreto, Lidyane V. Camelo, Sara T. Menezes, Naomi M. Hamburg, Maria de Fatima H. S. Diniz, Antonio L. P. Ribeiro, Luisa C. C. Brant   +7 more
wiley   +1 more source

Tablets and telehealth: expanding care reach by closing the digital divide. [PDF]

Health Aff Sch
Wilcher B, Jacobs J, Van Campen J, Greene L, Kimerling R, Zulman DM.   +5 more
europepmc   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

The FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal, Tomas Brom, Ivona Nečasová, Tomáš Janovič, Pavel Veverka, Naina Verma, Lukáš Uhrík, Lenka Hernychova, Ctirad Hofr   +8 more
wiley   +1 more source

Evaluation of salivary gland changes in menopausal women with xerostomia using the modified Schirmer test and ultrasonography. [PDF]

BMC Oral Health
Karacan Çelebi S, Paksoy CS.
europepmc   +1 more source

H2‐dependent modulation of tetrahydromethanopterin S‐methyltransferase (Mtr complex) activity by the small protein MtrR in Methanosarcina mazei

The FEBS Journal, EarlyView.
Small protein MtrR is a regulator of the Mtr methyltransferase complex in Methanosarcina mazei. It binds specifically to the MtrA subunit and modulates Mtr activity in response to hydrogen (H2) availability. Deleting mtrR impairs growth in the presence but not absence of H2, indicating its role in directing methyl transfer toward an energy‐conserving ...
Tim Habenicht, Bjarne Hastedt, Liam Cassidy, Claudia Kießling, Andreas Tholey, Jan M. Schuller, Ruth A. Schmitz   +6 more
wiley   +1 more source

An adaptive multi-scale spatio-temporal graph network for robust MOOC dropout prediction. [PDF]

Sci Rep
Duan Y, Chen X.
europepmc   +1 more source