Results 241 to 250 of about 72,051 (311)

Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization

The FEBS Journal, EarlyView.
PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe, Jiawei Xing, Xiansha Xiao, John A. Buglino, Huilin Li, Igor B. Zhulin, Michael S. Glickman   +6 more
wiley   +1 more source

The Origins of R. G. Collingwood's Philosophy of History in his Philosophy of Religion, 1916–1943

The Heythrop Journal, EarlyView.
Abstract This article argues that R.G. Collingwood's philosophy of history was deeply rooted in his early philosophy of religion as expounded in Religion and Philosophy (1916). Although scholars have tended to separate Collingwood's early religious ideas from his later writings, this study demonstrates that his theory of history was informed by his ...
Jacob Donald Chatterjee
wiley   +1 more source

Physics-Informed Graph Learning for Spatially Contiguous and Capacity-Constrained Hospital Service Area Delineation. [PDF]

Comput Environ Urban Syst
Liu L, Wang F.
europepmc   +1 more source

Additional sectioning and AI‐assisted diagnosis reveal underdiagnosis of serous (pre)malignancies in fallopian tube specimen from BRCA1/2 carriers

Histopathology, EarlyView.
This paper shows that deeper sections reveal additional STICs and HGSCs in risk‐reducing salpingo‐oophorectomy specimens of patients who did not have a STIC or HGSC diagnosis but did develop peritoneal HGSC 10 years after surgery. This adds to the premise that HGSC originates in the fallopian tube.
Anouk B Bouwmeester, Tamar A Gootzen, Marielle Nobbenhuis, Vilius Rudaitis, Caroline B van den Berg, Heleen J van Beekhuizen, Luthy SM Alcalá, Dineke PM Smedts, Nicole CM Visser, Viola Verhoef, Trudy GN Jonges, Ronald P Zweemer, Alicia Leon‐Catillo, Carlijn Lems, Joanne A de Hullu, Jeroen AWM van der Laak, Miranda P Steenbeek, Michiel Simons   +17 more
wiley   +1 more source

Oncometabolites in Cancer Metabolism: Mechanistic Insights and Biomarker Potential- A Narrative Review. [PDF]

Health Sci Rep
Khatun MM, Sarker MA, Podder MK, Biswas MS, Hasan MM, Tamannaa Z, Hossain MN, Badhon RS, Akter MA.   +8 more
europepmc   +1 more source

Immune Consequences of Metabolic Syndrome and Its Treatment: A Cytokine Perspective

Immunology, EarlyView.
Peripheral blood mononuclear cells (PBMCs) from individuals with metabolic syndrome (MetS) who were not using glucose‐and/or lipid lowering medication (GLLM) exhibited a broader cytokine production profile after in vitro antigen‐specific stimulation than PBMCs from individuals with MetS using such medications and from healthy donors.
Isabela Ghetti Macedo Isaac, Carolina do Prado Servian, Fernanda de Oliveira Feitosa de Castro, João Lucas Lima Calandrini de Azevedo, Ronaldo Moraes Preto, Miriam Leandro Dorta, Daniela Espíndola Antunes, Simone Gonçalves Fonseca   +7 more
wiley   +1 more source

Group Therapy for Posttraumatic Stress Disorder Symptoms Among Veterans With Military Sexual Trauma: A Randomized Clinical Trial.

JAMA Netw Open
Wood AE, Zaccari BA, Hee Wai TY, Crooker MN, Evanisko MS, Clark JB, Sewell JB, Silverman SC, Dolph SJ, Katz LS.   +9 more
europepmc   +1 more source

Integrated multi-omics analysis uncovers cervicovaginal ecological networks and their association with <i>Chlamydia trachomatis</i> load. [PDF]

Infect Immun
Ardizzone CM, Lammons JW, Lan RS, Elnaggar JH, Lillis RA, Toh E, Pack LM, Mott PD, Jacobs CD, Yeruva L, Taylor CM, Quayle AJ.   +11 more
europepmc   +1 more source

The application of machine learning models to optimal TSP tour length estimation

International Transactions in Operational Research, EarlyView.
Abstract The traveling salesman problem (TSP) is a well‐known NP‐hard problem in combinatorial optimization, with numerous applications in logistics and elsewhere. This paper introduces a machine learning‐based approach to estimate the optimal tour length of the TSP, using linear regression, random forests (RF), and neural networks, including ...
Shuhan Kou, Bruce Golden, Luca Bertazzi
wiley   +1 more source

[Coupling characteristics of cellular electroporation and electrodeformation based on dynamic Young's modulus: influence of membrane thickness]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
Wei X, Zou S, Guo F, Liu L.
europepmc   +1 more source