Results 271 to 280 of about 401,475 (303)
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Gan to kagaku ryoho. Cancer & chemotherapy, 2011
Mammalian target of rapamycin(mTOR)exists downstream in the PI3K/AKT signal transmission pathway that is constantly activated in many cancers. It regulates translation of mRNA that codes for proteins involved in survival signals, such as for the cell cycle and apoptosis, by phosphorylation of p70S6K and 4E-BP1 that are further downstream.
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Mammalian target of rapamycin(mTOR)exists downstream in the PI3K/AKT signal transmission pathway that is constantly activated in many cancers. It regulates translation of mRNA that codes for proteins involved in survival signals, such as for the cell cycle and apoptosis, by phosphorylation of p70S6K and 4E-BP1 that are further downstream.
openaire +1 more source
mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity
Cell, 2022Antonio J Pagán +2 more
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Making new contacts: the mTOR network in metabolism and signalling crosstalk
Nature Reviews Molecular Cell Biology, 2014Mitsugu Shimobayashi, Michael N Hall
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Current development of mTOR inhibitors as anticancer agents
Nature Reviews Drug Discovery, 2006Guido Kroemer
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Amino acid signalling upstream of mTOR
Nature Reviews Molecular Cell Biology, 2013Jenna L Jewell +2 more
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mTOR signalling and cellular metabolism are mutual determinants in cancer
Nature Reviews Cancer, 2018Michael N Hall
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