Results 61 to 70 of about 384,173 (308)

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Profitability bookkeeping in the reindeer husbandry

Rangifer, 2007
See extended abstract in Full ...
Arto Latukka, Olli Rantala, Jukka Tauriainen   +2 more
doaj   +1 more source

The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer

OncoTarget, 2016
Inconsistencies in the half-maximal (50%) inhibitory concentration (IC50) data for anticancer chemotherapeutic agents have yielded irreproducible experimental results and thus reciprocally contradictory theories in modern cancer research.
Yifeng He, Qiu-jing Zhu, Mo Chen, Qihong Huang, Wenjing Wang, Qing Li, Yuting Huang, W. Di   +7 more
semanticscholar   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Strategic objectives and development plans of beginning farmers

Agricultural and Food Science, 2012
Taking over the management and ownership of a farm contributes positively to farm growth but little is known about how farmers succeed after the starting phase.
Leena Rantamäki-Lahtinen, Minna Katriina Väre   +1 more
doaj  

Evaluation of concentrate factors affecting silage intake of dairy cows: a development of the relative total diet intake index

Animal, 2008
The aim of this work was to develop an index describing the relative intake of the total diet by dairy cows, and hence the ability to predict intake responses to changes in both forage and concentrate variables.
P. Huhtanen, M. Rinne, J. Nousiainen
doaj   +1 more source

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

Climate change adaptation in arable land use, and impact on nitrogen load at catchment scale in northern agriculture

Agricultural and Food Science, 2013
Prolongation of the growing season due to a warming climate could represent new opportunities for northern agriculture. Climatic and biotic constraints may challenge future crop production.
Katri Rankinen, Pirjo Peltonen-Sainio, Kirsti Granlund, Hannu Ojanen, Mikko Laapas, Kaija Hakala, Kalle Sippel, Juha Helenius, Martin Forsius   +8 more
doaj  

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Protein crop production at the northern margin of farming: to boost or not to boost

Agricultural and Food Science, 2012
Global changes in food demand resulting from population growth and more meat-intensive diets require an increase in global protein crop production, not least as climate change and increasing scarcity of fresh water could restrict future production.
Pirjo Peltonen-Sainio, Jarkko K. Niemi
doaj