Results 21 to 30 of about 4,749 (196)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Trait Mindfulness as a Protective Factor in Connections between Psychological Issues and Facebook Addiction among Turkish University Students

Studia Psychologica, 2020
Facebook addiction is a growing issue that has increasingly attracted the attention of clinicians and researchers in a variety of countries and cultures.
Mustafa Eşkisu, Zekeriya Çam, Sedat Gelibolu, Kyler Ray Rasmussen   +3 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Muş Ovasında Beyaz Lahana Üreticiliği: Bağlar Köyü Örneği

Doğu Coğrafya Dergisi
Bitkisel üretim, insanların temel besin maddesi ihtiyacını karşıladığından dolayı önemini korumaktadır. Son yıllarda tarım alanlarının amacı dışında kullanımının artması ve küresel ölçekte etkili olan pandemi ve bölgesel savaşların gıdaya erişimi ...
İrfan Baytar
doaj   +1 more source

Global investigation of the ionospheric irregularities during the severe geomagnetic storm on September 7–8, 2017

Geodesy and Geodynamics, 2020
In this study, the global effects of the severe geomagnetic storm on the Earth's ionosphere on September 5–9, 2017 with Coronal Mass Ejections (CMEs) associated with X-9.3 flares on September 6, 2017 were investigated by the Rate of Total Electron ...
Ramazan Atıcı, Selçuk Sağır
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Spor Lisesi Öğrencilerinin Yeni Tip Koronavirüse (Covid 19) Yakalanma Kaygılarının İncelenmesi (Doğu Anadolu Bölgesi Örneği)

Spor Bilimleri Araştırmaları Dergisi, 2022
Dünya Sağlık Örgütü tarafından, küresel bir salgın olarak nitelendirilen ve 2020 yılının başından itibaren hızla dünyayı etkisi altına alan Covid-19 pandemisi hem bireyler hem de toplumlar üzerinde fiziksel, duygusal, sosyal ve iktisadi boyutta birçok ...
Alper Karadağ, Harun Koç
doaj   +1 more source

Synergistic All‐in‐One Electroceutical Platform Utilizing a Plasma–Photodynamic Hybrid Approach for Enhanced Wound Healing

Advanced Functional Materials, EarlyView.
A flexible hybrid patch integrating a robust cold atmospheric plasma (CAP) system with a high‐power, ultrathin bio‐OLED was developed to enable synergistic wound healing. This multimodal therapy, combining plasma and photodynamic treatment, enhanced angiogenesis, cell proliferation, and collagen deposition, demonstrating superior in vivo efficacy and ...
Jun‐Yeop Song, Hyun Cheol Bang, Young Hyun Son, Dae‐In Ha, Eun‐Ju Hong, Sun‐Woo Lee, Jeongsook Kim, Doyeong Kim, Sang‐Min Park, Kyu Pil Lee, Hyo‐Jung Kwon, Jeong Hyun Kwon   +11 more
wiley   +1 more source

Ferritin‐Doped Nanoparticles Triggered Tumor‐Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation

Advanced Healthcare Materials, EarlyView.
Ferritin‐doped hybrid nanoparticles triggered accurate tumor‐specific hemorrhage for enhanced in situ photothermal therapy and evoked anti‐tumor immunity. Notably, HFn/GA‐Fe specifically induced tumor hemorrhage 12 h after intravenous injection, resulting in visible color darkening. Through photoacoustic imaging, tumor vessels could be clearly observed
Haidong Zha, Xiao Liang, Long Xi, Jiamao Chen, Wenzhao Zhong, Zhen Yuan, Meng Xu, Ying Zheng   +7 more
wiley   +1 more source

Modified Roller Coaster Surface in Space

Mathematics, 2019
In this paper, a new modified roller coaster surface according to a modified orthogonal frame is investigated in Euclidean 3-space. In this method, a new modified roller coaster surface is modeled. Both the Gaussian curvature and mean curvature of roller
Selçuk BAŞ, Talat KÖRPINAR
doaj   +1 more source