Results 51 to 60 of about 14,453 (243)

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

DÜZEY 2 SINIFLANDIRMASINA GÖRE MEVCUT HAYVANCILIK DURUM ANALİZİ, MEKÂNSAL VE ZAMANSAL DAĞILIŞ: TRB2 ÖRNEĞİ

Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2019
Hayvan sayısı ve niteliği küresel düzeyde olduğu gibi yerel düzeyde de hem ekonomi hem beslenme alanlarında hayati öneme sahiptir. Hızla artan dünya nüfusuna karşılık dünya hayvan sayısında azalışların olması düşünülmesi ve değerlendirilmesi ...
Numan Ertaş
doaj  

Matematik Öğretiminde Aile-Ebeveyn Katılımının Önemi: Kapsamlı Bir Derleme

İçtimaiyat
Bu derleme, aile ve ebeveyn katılımının matematik eğitimi üzerindeki çok boyutlu etkilerini, çocukların akademik başarı, motivasyon, özgüven ve matematiksel düşünme becerilerinin gelişimi bağlamında kapsamlı biçimde incelemektedir.
Semih Uçar, Yılmaz Mutlu, Yavuz Erdem, İhsan Söylemez   +3 more
doaj   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Comparison of circumcisions performed before and during adolescence [PDF]

, 2013
aimed to compare the complication rates of circumcisions that were performed before and during adolescence in our area.Methods: 296 uncircumcised boys aged between 8 and 20 years were enrolled.
İsmail yağmur, Mansur Dağgülü, Mehmet Mazhar Utanğaç   +2 more
core   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

The Effect of Robotics and Coding Education on Girls’ STEM Motivation, Attitude and Career Aspirations

SAGE Open
STEM education aims to develop 21st-century skills, support economic growth and promote gender equality in STEM fields. It is known that gender stereotypes play a significant role in the formation of STEM identity.
Salih Gülen, İsmail Dönmez, Fatma Betül Şengönül, Miyase Aslantaş, Turgut Saritaş, Ömer Sukenari, Emrah Eke, Semih Uçar   +7 more
doaj   +1 more source

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

MUŞ’UN BAZI KÖYLERİNDE DIRINDIZ VE TELALEDÂDAN GELENEKLERİ ÜZERİNE BİR DEĞERLENDİRME

Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2019
İnançların, tarih aşan özelliği vardır. Bir dine ait bazı kadim uygulamaların, başka din ve kültürlerde varlıklarını korudukları görülebilir. Dolayısıyla bir bölgedeki halk inanışları araştırıldığında eskiye dair birçok ize rastlanılabilir.
Mehmet Emin Sular
doaj  

Investigation of commonly used assessment methods for predicting fall risk in the elderly

Experimental Gerontology
Aim: This study aimed to evaluate the effectiveness of four different commonly used assessment methods Berg Balance Scale (BBS), Timed Up and Go Test (TUG), Modified Falls Efficacy Scale (MFES), and Morse Fall Scale (MFS) in predicting fall risk in ...
Aziz DENGİZ, Ahmet AYTEPE, Bayram SIRRI, Mehmet EFE   +3 more
doaj   +1 more source