Results 201 to 210 of about 17,478 (246)
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Journal of Controlled Release, 1998
The ability of mucoadhesive polymers to produce a large increase in the resistance to deformation when incorporated into a mucus gel, relative to when the mucus gel and test materials are evaluated separately at the same concentrations, has been reported in several previous studies.
F, Madsen, K, Eberth, J D, Smart
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The ability of mucoadhesive polymers to produce a large increase in the resistance to deformation when incorporated into a mucus gel, relative to when the mucus gel and test materials are evaluated separately at the same concentrations, has been reported in several previous studies.
F, Madsen, K, Eberth, J D, Smart
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Drug Development and Industrial Pharmacy, 2007
The aim of this study was to characterize a buccal mucoadhesive film using lidocaine and its hydrochloride salt (LDHCL) as a model drug. Buccal films were developed using carbopol 971P as a mucoadhesive polymer, and glycerol as a plasticizer. Scanning Electron Microscope, Differential Scanning Calorimetry, X-ray powder diffraction, and Fourier ...
Rana, Abu-Huwaij +3 more
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The aim of this study was to characterize a buccal mucoadhesive film using lidocaine and its hydrochloride salt (LDHCL) as a model drug. Buccal films were developed using carbopol 971P as a mucoadhesive polymer, and glycerol as a plasticizer. Scanning Electron Microscope, Differential Scanning Calorimetry, X-ray powder diffraction, and Fourier ...
Rana, Abu-Huwaij +3 more
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Mucoadhesion: a review of characterization techniques
Expert Opinion on Drug Delivery, 2010Mucoadhesive drug delivery vehicles attract much attention owing to benefits such as extended residence time of the drug at the site of application, a relatively rapid uptake of a drug into the systemic circulation, and enhanced bioavailability of therapeutic agents.
Maya, Davidovich-Pinhas +1 more
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Investigation of correlations between mucoadhesion and surface energy properties of mucoadhesives
Journal of Applied Polymer Science, 2006AbstractTo explore the correlations between mucoadhesion and the surface properties of mucoadhesive polymers, a series of polymer, poly[acrylic acid‐co‐poly(ethylene glycol) monomethylether monomethacrylate‐co‐dimethylaminoethyl methacrylate], poly(AA‐PEGMM‐DMEMA), was designed and synthesized as a model mucoadhesive in this study. Poly(AA‐PEGMM‐DMEMA)
Jun Xiang, Xiaoling Li
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Mucoadhesive Delivery Systems. I. Evaluation of Mucoadhesive Polymers for Buccal Tablet Formulation
Drug Development and Industrial Pharmacy, 2004Different types of mucoadhesive polymers, intended for buccal tablet formulation, were investigated for their comparative mucoadhesive force, swelling behavior, residence time and surface pH. The selected polymers were carbopols (CP934, and CP940), polycarbophil (PC), sodium carboxymethyl cellulose (SCMC) and pectin representing the anionic type, while
Noha Adel, Nafee +3 more
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Nanoscale technology of mucoadhesive interactions
Advanced Drug Delivery Reviews, 2004Nanoscale analysis may be used to design new types of mucoadhesive polymers. Understanding of the surface interactions between hydrophilic polymer surfaces and mucins can lead to improved adhesive bonding by hydrogen bonding. Alternatively, decoration of a mucoadhesive polymer surface with tethers of linear and block copolymers containing neutral or ...
Nicholas A, Peppas, Yanbin, Huang
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The basics and underlying mechanisms of mucoadhesion
Advanced Drug Delivery Reviews, 2005Mucoadhesion is where two surfaces, one of which is a mucous membrane, adhere to each other. This has been of interest in the pharmaceutical sciences in order to enhance localised drug delivery, or to deliver 'difficult' molecules (proteins and oligonucleotides) into the systemic circulation.
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