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Mucosal Adjuvants

Vaccine, 2005
Induction of immune responses following oral immunization is frequently dependent upon the co-administration of appropriate adjuvants that can initiate and support the transition from innate to adaptive immunity. The three bacterial products with the greatest potential to function as mucosal adjuvants are the ADP-ribosylating enterotoxins (cholera ...
L C, Freytag, J D, Clements
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Mucosal Adjuvants

Current HIV Research, 2010
The vast majority of pathogens invade the body through or establish infections in the mucosal tissues. Development of vaccines to combat mucosal infections represents a top priority. Mucosal immunization has recently attracted much interest as a means of generating protective immunity against mucosal pathogens.
HARANDI A. M., MEDAGLINI D.
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Mucosal Immunoglobulins

Immunological Reviews, 2005
Summary:  Due to their vast surface area, the mucosal surfaces of the body represent a major site of potential attack by invading pathogens. The secretions that bathe mucosal surfaces contain significant levels of immunoglobulins (Igs), which play key roles in immune defense of these surfaces.
Woof, Jenny M., Mestecky, Jiri
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Oral Mucositis

Clinical Journal of Oncology Nursing, 2006
Ms. J is a 55-year-old woman who was diagnosed with stage IIIA colon cancer three months ago. Prior to her diagnosis, she experienced an unintentional 17-pound weight loss. She underwent an exploratory laparotomy with colon resection. Following recovery from her surgery, she began an adjuvant chemotherapy regimen of 5-fluorouracil, leucovorin, and ...
C, Scully, S, Sonis, P D, Diz
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MUCOSAL IMMUNITY*

Annals of the New York Academy of Sciences, 1983
Mucosal defense is provided by a number of host factors countering the specific virulence factors of the many microorganisms infecting the mucous membranes. Secretory IgA antibodies presumably play an important role. Increase of the sIgA antibodies may most advantageously be attained by parenteral immunization, following mucosal priming.
L A, Hanson   +14 more
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Mucositis

Current Opinion in Oncology, 2015
Oral mucositis remains a frequent debilitating toxicity associated with drug and radiation regimens used to treat cancer. This review highlights the recent understanding of the biological basis, risk factors for, and management for oral mucositis.Prevalence and incidence data for mucositis are inconsistent and often underreported.
Alessandro, Villa, Stephen T, Sonis
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Mucosal Melanoma

Clinics in Plastic Surgery, 2021
Mucosal melanoma is a rare but aggressive cancer arising in mucosal surfaces most commonly in the head and neck. The clinical presentation is often nonspecific and differs in relation to the site of origin so often diagnosis is delayed resulting in poor prognosis. Mucosal melanoma has a 5-year survival of only 25%.
Danielle, Olla, Michael W, Neumeister
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Mucosal Immunity

Pediatrics, 2003
Food allergy is the manifestation of an abnormal immune response to antigen delivered by the oral route. Normal mucosal immune responses are generally associated with suppression of immunity. A normal mucosal immune response relies heavily on a number of factors: strong physical barriers, luminal digestion of potential antigens, selective antigen ...
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Gastrointestinal mucositis

Seminars in Oncology Nursing, 2004
To review the management of radiotherapy- and chemotherapy-induced gastrointestinal mucositis.Articles and research studies.Gastrointestinal damage is becoming a common dose-limiting toxicity. However, there is only limited research into the mechanism and possible treatment of this toxicity.It is important to document the frequency and severity of ...
Keefe, D., Gibson, R., Hauer-Jensen, M.
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Oral mucositis

Dental Clinics of North America, 2005
Oral mucositis refers to erythematous, erosive, and ulcerative lesions of the oral mucosa seen in two patient populations: (1) head and neck cancer patients undergoing radiation therapy to fields involving the oral cavity, and (2) patients receiving high-dose chemotherapy for cancer.
Rajesh V, Lalla, Douglas E, Peterson
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