Results 61 to 70 of about 1,288,751 (244)

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Mucous membrane pemphigoid in a patient with hypertension treated with atenolol: a case report

Journal of Medical Case Reports, 2012
Introduction Atenolol is commonly used by patients with hypertension, angina pectoris, or myocardial infarction. There have been reports of various adverse effects associated with the use of atenolol including bullous pemphigoid.
Kanjanabuch Patnarin, Arporniem Samornroj, Thamrat Suparat, Thumasombut Pannipa   +3 more
doaj   +1 more source

Mucous Membrane Pemphigoid-Immunofluorescent Studies

, 1969
Mucous membrane pemphigoid differs from pemphigus vulgaris or bullous pemphigoid in clinical course, response to steroid therapy, and absence of characteristic antibodies.
Harvey A. Brody, Kirk D. Wuepper
core   +1 more source

HIV Patient with Mucous Membrane Pemphigoid: A Case Report [PDF]

, 2014
Background: Mucous Membrane Pemphigoid, a new denomination of cicatricial pemphigoid, encompasses a group of chronic subepithelial autoimmune blistering diseases that predominantly affect the oral cavity and the eyes (conjunctivitis and symblepharon ...
Singh, SP, Mohapatra, AK, Ravishankar, TL, Singh, AP, Chaitra, TR   +4 more
core   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Interconnection between aggression and protection factors of gastric juice and oral liquid of the patients with precancerous changes of gastric mucosa

Journal of Education, Health and Sport, 2019
This article is about learning of the aggression factors and the gastric juice and oral liquid protection of the patients with precancerous changes in the mucous gastric membrane of stomach.
A. I. Rudenko, L. M. Mosiychuck, O. M. Khomenko, O. P. Petishko   +3 more
doaj   +3 more sources

Drug-induced oral mucous membrane pemphigoid: a case report

, 2017
Observation: An 82-year-old patient treated with the antihistamine ebastine (Kestin®) for allergic rhinitis presented for gingival pain. The diagnosis of mucous membrane pemphigoid was suspected after a positive pinch test. Blood examinations highlighted
Bastien Bercault, Jean-Christophe Fricain, Mathilde Fenelon, Sylvain Catros, Jean-Marie Marteau   +4 more
core   +1 more source

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

Immunohistochemical evaluation of oestrogen receptors α and β in epithelium of the vaginal mucous membrane in women after oestrogen therapy [PDF]

, 2017
Oestrogens act on target cells through α and β receptors (ERα and ERβ). Expression of oestrogen receptors is associated with the age and menopausal condition of women.
Lech Chyczewski, Beata Sawczuk, Maria Gołębiewska, Andrzej Mazurek   +3 more
core   +1 more source