Results 1 to 10 of about 8,392 (166)

Mullerian inhibiting substance requires its N-terminal domain for maintenance of biological activity, a novel finding within the transforming growth factor-beta superfamily [PDF]

Molecular Endocrinology, 1993
Mullerian inhibiting substance (MIS)/anti-Mullerian hormone is a differentiation factor that causes regression of the Mullerian duct in the developing male fetus and an apparent sex reversal of the fetal ovary when inappropriately exposed to it. The purified product is a 140-kilodalton glycoprotein composed of two identical subunits.
C A, Wilson, N, di Clemente, C, Ehrenfels, R B, Pepinsky, N, Josso, B, Vigier, R L, Cate   +6 more
exaly   +5 more sources

Pathogenesis of Adenomyosis: An Integrated Review of Cellular Origins, Molecular Mechanisms, and Intersecting Diseases. [PDF]

J Cell Mol Med
ABSTRACT Adenomyosis is a prevalent disorder of the archimetra, historically conflated with endometriosis but possessing a unique pathobiological trajectory. This review synthesises current molecular evidence to propose a unified mechanistic framework initiated by tissue injury and repair (TIAR), aberrant stem cell activation, or de novo metaplasia ...
Yang J, Li X, Peng Y, Sun Z, Zhang L, Duan J, Zhong N.   +6 more
europepmc   +2 more sources

Sex-Specific Gene Expression Ontogeny During Gonadal Development in Post-Metamorphic Xenopus tropicalis. [PDF]

Mol Reprod Dev
Post‐metamorphic gonadal development in Xenopus tropicalis was analyzed through integrated morphometric, histological, and transcriptional approaches. Males showed upregulation of cyp17, amh, and amhr2, whereas females exhibited an increased aldh1a2 and ddx4.
Marini D, Roza M, Berg C, Brouard V.
europepmc   +2 more sources

TGF-β Signaling in the Pathophysiology of the Ovary: A Double-Edged Regulator [PDF]

Biomolecules
The Transforming Growth Factor-β (TGF-β) superfamily comprises highly conserved cytokines that orchestrate key cellular functions, including proliferation, differentiation, and apoptosis. Within the ovary, TGF-β family members serve as pivotal regulators
Nicole Bertani, Alessandra Alteri, Luciana Cacciottola, Giorgia D’Addato, Gina La Sala, Biliana Lozanoska-Ochser, Micol Massimiani, Edoardo Parrella, Alessio Reggio, Eleonora Russo, Federica Campolo, Francesca Gioia Klinger   +11 more
doaj   +2 more sources

Obstructed inguinal hernia in an adult male: A rare presentation of persistent Müllerian duct syndrome (internal male pseudohermaphroditism): A case report

International Journal of Abdominal Wall and Hernia Surgery, 2022
Persistent Müllerian duct syndrome (PMDS) is an unusual form of internal male pseudohermaphroditism in which Müllerian duct derivatives are seen in phenotypically normal males, with 46, XY karyotype.
Musharraf Husain, Sabina Khan, Sanika Deshpande, Kartavya S Yadav   +3 more
doaj   +1 more source

MRI findings of Persistent Mullerian Duct Syndrome: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2017
Embryologically mullerian duct derivatives lead to formation of female genitalia and wolffian duct derivatives to male genitalia. Presence of mullerian duct derivatives in a chromosomally normal male (XY) leads to male pseudohermaphroditism and is ...
RAMBIR SINGH, SUNIL D KUMAR, NIDHI AGGARWAL   +2 more
doaj   +1 more source

Mullerian Inhibiting Substance acts as a motor neuron survival factor in vitro [PDF]

Proceedings of the National Academy of Sciences, 2005
The survival of motor neurons is controlled by multiple factors that regulate different aspects of their physiology. The identification of these factors is important because of their relationship to motor neuron disease. We investigate here whether Mullerian Inhibiting Substance (MIS) is a motor neuron survival factor.
Pei-Yu, Wang, Kyoko, Koishi, Andrew B, McGeachie, Michael, Kimber, David T, Maclaughlin, Patricia K, Donahoe, Ian S, McLennan   +6 more
openaire   +3 more sources

Persistent mullerian duct syndrome

Indian Journal of Radiology and Imaging, 2010
Persistent Mullerian duct syndrome (PMDS) is a rare form of internal male pseudohermaphroditism in which Mullerian duct derivatives are seen in a male patient. This syndrome is characterized by the persistence of Mullerian duct derivatives (i.e.
Divya Renu, B Ganesh Rao, K Ranganath
doaj   +3 more sources

Chemotherapy: Impact on Anti-Müllerian Hormone Levels in Breast Carcinoma [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Anti-Mullerian Hormone (AMH) is a glycoprotein of the transforming growth factor-β (TGF-β) family that seems to reflect the continuous non-cyclical growth of small follicles and can be considered an indirect index of the size of the ...
Jyoti Bala, Shashi Seth, Rakesh Dhankhar, Veena Singh Ghalaut   +3 more
doaj   +1 more source

Mullerian-Inhibiting Substance Induces Gro-β Expression in Breast Cancer Cells through a Nuclear Factor-κB–Dependent and Smad1-Dependent Mechanism [PDF]

Cancer Research, 2007
AbstractMullerian-inhibiting substance (MIS), a transforming growth factor-β family member, activates the nuclear factor-κB (NF-κB) pathway and induces the expression of B-cell translocation gene 2 (BTG2), IFN regulatory factor-1 (IRF-1), and the chemokine Gro-β.
Vandana, Gupta, Giminna, Yeo, Hirofumi, Kawakubo, Vivek, Rangnekar, Preethi, Ramaswamy, Tetsu, Hayashida, David T, MacLaughlin, Patricia K, Donahoe, Shyamala, Maheswaran   +8 more
openaire   +2 more sources