Results 51 to 60 of about 4,325,305 (154)

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, EarlyView.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

Dynamic Domain Links Substrate Binding and Catalysis in the Factor-Inhibiting-HIF‑1

, 2023
The interplay between active-site chemistry and functionally relevant enzyme motions can provide useful insights into selective enzyme modulation.
Michael J. Knapp (1335075), Cristina B. Martin, Cornelius Y. Taabazuing, Cristina B. Martin (7407269), Cornelius Y. Taabazuing (1603345), Michael J. Knapp   +5 more
core   +1 more source

Incretin‐Based Medications in Women and Reproduction: A Systematic Scoping Review and Consensus Guidelines for Clinical Practice

Obesity Reviews, EarlyView.
ABSTRACT Introduction Pregnancy concurrent with incretin‐based medications is contraindicated due to unknown risk of teratogenicity, as is breastfeeding. The aim of this systematic scoping review was to investigate potential risks and benefits of incretin‐based medications in relation to preconception, pregnancy, and postnatal health, and to propose ...
Kate Maslin, Jill Shawe, Sinead Blowers, Michael Ceulemans, Kathryn Hart, Sam Schoenmakers, Amihai Rottenstreich, Heather Hopper, Mojca Jensterle, Angela C. Flynn, Sarah Siegelaar, Annick Bogaerts, Isy Douek, Nicola Heslehurst, Dries Ceulemans, Tricia Tan, Johnathan Pinkney, Martin Whyte, Shahrad Taheri, Roland Devlieger   +19 more
wiley   +1 more source

miR-149-5p mitigates tumor necrosis factor-α-induced chondrocyte apoptosis by inhibiting TRADD

, 2020
Introduction Chondrocyte apoptosis as a prominent characteristic is usually accompanied by cartilage degeneration in osteoarthritis (OA). Herein, we aimed to determine the roles of miR-149-5p in tumor necrosis factor-α (TNF-α)-induced chondrocyte ...
Shi-cheng Xie, Lin Yang, Wenbo Wang, Taipengfei Shu, Qin Liu   +4 more
core   +1 more source

Exploring lifestyle management in polycystic ovary syndrome through implementation frameworks

Experimental Physiology, EarlyView.
Abstract Polyendocrine metabolic ovarian syndrome [PMOS; previously known as polycystic ovary syndrome (PCOS)] is an endocrine condition affecting 10%–13% of women of reproductive age, with cardiometabolic, reproductive and psychological features. The PMOS guidelines have established recommendations for its management, which can include pharmacological,
Margaret McGowan, Stephanie Cowan, Chau Thien Tay, Lisa J. Moran, Ashley H. Ng   +4 more
wiley   +1 more source

hUC-MSC Combined with DHEA Alleviates Ovarian Senescence in Naturally Aging Mice through Enhancing Antioxidant Capacity and Inhibiting Inflammatory Response

Stem Cells International
The ovary is an important organ for women to maintain reproductive and endocrine functions. Ovarian aging can lead to female reproductive aging, which is a key factor causing rapid aging of the female body.
Chun-Yi Guan, Dan Zhang, Xue-Cheng Sun, Xu Ma, Hong-Fei Xia   +4 more
doaj   +1 more source

Paraurethral Endometrioid Carcinoma Arising From Ectopic Endometriosis: A Case Report

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Malignant transformation of endometriosis is rare and most commonly involves the ovary; transformation from paraurethral endometriosis is exceedingly rare. Case Presentation A 73‐year‐old postmenopausal woman with prior ovarian endometrioma presented with dysuria and voiding difficulty.
Keita Ogasawara, Takashi Tsuyukubo, Mizuki Hisano, Hiromitsu Fujisawa, Shigekatsu Maekawa, Mitsugu Kanehira, Mitsumasa Osakabe, Naoki Yanagawa, Hiroaki Itamochi, Wataru Obara   +9 more
wiley   +1 more source

Bushen Huoxue formula attenuates lipid accumulation evoking excessive autophagy in premature ovarian insufficiency rats and palmitic acid-challenged KGN cells by modulating lipid metabolism

Frontiers in Pharmacology
IntroductionPremature ovarian insufficiency (POI) has affected about 3.7% of women of reproductive age and is a major factor contributing to infertility.
Tian Li, Tian Li, Yao Wei, Beibie Jiao, Beibie Jiao, Rui Hao, Beibei Zhou, Xinlan Bian, Xinlan Bian, Peijuan Wang, Yahong Zhou, Xia Sun, Xia Sun, Jian Zhang, Jian Zhang, Jian Zhang   +15 more
doaj   +1 more source

Network Pharmacology and In Vivo Evaluation of Modified Huanglian Wendan Decoction in Polycystic Ovary Syndrome With Insulin Resistance: Association With AGE–RAGE‐Related Signaling

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
An integrated network pharmacology, chemical profiling, molecular docking, molecular dynamics, and in vivo strategy shows that Modified Huanglian Wendan Decoction improves reproductive and metabolic abnormalities in a rat model of PCOS with insulin resistance.
Xi Chen, Xing Yang, Xinni Wang, Dan Chou, Chenghong Zheng   +4 more
wiley   +1 more source

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, Volume 175, Issue 1, Page 26-47, October 2026.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source