Results 41 to 50 of about 51,610 (211)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Research on distributed multi-access edge computing based on mimic defense theory
物联网学报, 2019 The highly efficient network resources are provided by multi-access edge computing at the edge of the network,but high security capability is required also due to its distributed position and organization.Based on mimic defense theory,mimic defense ...
Hongyi ZHU, Xiaoyuan LU, Yi LI
doaj +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
A survey on edge computing offloading
Dianxin kexue, 2019 Edge computing integrate the computing,storage and other resources on the edge of the network into a unified user service platform.According to the principle of nearest service,the network edge node task request is timely and correspondingly processed ...
Youkang ZHU +3 more
doaj +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
IEEE Access, 2019 With the rapid development of the Internet of Things and the ever-increasing demands of advanced services and applications, edge computing is proposed to move the computing and storage resources near the data source, which improves the response time and ...
Youhuizi Li +5 more
doaj +1 more source
Joint scheduling algorithm for correlative tasks in multi-access edge computing
Tongxin xuebao, 2023 Multi-access edge computing (MEC) has emerged as a promising computing paradigm for resource-intensive applications.However, most of the previous research work has not considered correlative tasks, which may lead to infeasible scheduling decisions ...
Weifeng LU +4 more
doaj +2 more sources