Results 221 to 230 of about 4,514,037 (280)

Enhancing financial data collection and reporting in small businesses through IoT integration: an exploration of IFRS standard. [PDF]

Front Artif Intell
Oraby S, Johri A, Sayal A, Chong KM, Alhumoudi H, Jha J, N C.   +6 more
europepmc   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Multi-level determinants of comprehensive palliative care delivery for breast and cervical cancer patients in Ethiopia: using the socio-ecological model as an analytical framework. [PDF]

BMC Palliat Care
Deribe KS, Shewaye S, Habtamu NS, Wondimagegnehu A, Azmera YM, Addissie A, Kantelhardt EJ, Kaba M.   +7 more
europepmc   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Economic Impact of Malignant Catarrhal Fever on Cattle Production in Lephalale Municipality, Limpopo Province, South Africa. [PDF]

Vet Sci
Shiba W, Matle I, Zantsi S, Seakamela E.
europepmc   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Examining the effectiveness of financial vs. social incentives to participate in a smartphone ecological momentary assessment well-being study: protocol for a randomized controlled trial. [PDF]

Front Digit Health
Ridwan AR, Carter LA, Benton JS, Anderson J.   +3 more
europepmc   +1 more source

Hydrogen-Based Long-Duration Energy Storage: Technologies, System Integration, and Techno-Economic Performance. [PDF]

Glob Chall
Haggam RA, Javed S, Van Minh N, Sivanraju R, Prabhakar P.   +4 more
europepmc   +1 more source

Preliminary Effects of the ANZANSI Family Program on Caregiver Outcomes in Northern Ghana: A Pilot Study. [PDF]

Fam Soc
Bahar OS, Byansi W, Ibrahim A, Boateng A, Kumbelim K, Amissah FG, Childress S, Ssewamala FM, McKay MM.   +8 more
europepmc   +1 more source