Results 61 to 70 of about 2,673,797 (306)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multi-Criteria Decision Analysis to Develop an Efficacy-Safety Profile of Parenteral Analgesics Used in the Treatment of Postoperative Pain

Journal of Pain Research, 2020
Stephan Schug,1,2 Esther Pogatzki-Zahn,3 Lawrence D Phillips,4 Margaret Noyes Essex,5 Feng Xia,5 Alison J Reader,6 Robert Pawinski6 1Discipline of Anaesthesiology and Pain Medicine, Medical School, University of Western Australia, Perth, WA, Australia ...
Schug S, Pogatzki-Zahn E, Phillips LD, Essex MN, Xia F, Reader AJ, Pawinski R   +6 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Multi‐criteria IoT resource discovery: a comparative analysis [PDF]

Software: Practice and Experience, 2016
SummaryThe growth of real‐world objects with embedded and globally networked sensors allows to consolidate the Internet of things paradigm and increase the number of applications in the domains of ubiquitous and context‐aware computing. The merging between cloud computing and Internet of things named cloud of things will be the key to handle thousands ...
Luiz H. Nunes, Júlio Cézar Estrella, Charith Perera, Stephan Reiff‐Marganiec, Alexandre Cláudio Botazzo Delbem   +4 more
openaire   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A Multi Linear Discriminant Analysis Method Using a Subtraction Criteria

پژوهش‌های ریاضی, 2017
Linear dimension reduction has been used in different application such as image processing and pattern recognition. All these data folds the original data to vectors and project them to an small dimensions.
m rezghi, amin rastegar
doaj  

Beyond CO2: A multi-criteria analysis of air pollution in Europe

Journal of Cleaner Production, 2019
Environmental-economic perspectives are recently taking growing momentum in the analysis of country-level performances, but few studies take into account the multi-dimensional nature of the phenomenon.
Nicola Caravaggio, Serenella Caravella, A. Ishizaka, Giuliano Resce   +3 more
semanticscholar   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Model for Definition of Multi-Criteria Compensation by the ICCI (Inter-Criteria Compensation Index) in the Ranking of Electric Vehicles

Energies
Defining compensatory interactions among criteria is a critical yet often subjective step in multi-criteria decision analysis (MCDA). To address this gap, this study proposes a novel model centered around the Inter-Criteria Compensation Index (ICCI ...
Maiquiel Schmidt de Oliveira, Flavio Trojan, Vilmar Steffen   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source