Results 171 to 180 of about 79,223 (384)

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Screening helper T lymphocyte epitopes based on IFN-γ/IL-10 ratio for developing a novel multi-epitope vaccine candidate using Wolbachia surface protein as an adjuvant against visceral leishmaniasis

Parasites & Vectors
Background Visceral leishmaniasis (VL) is the most lethal form of leishmaniasis. In terms of anti-leishmanial vaccines, favorable immune responses are Th1 responses that primarily produce interferon gamma (IFN-γ) and activate macrophages for ...
Jianhui Zhang, Tianhang Lv, Shuoyan Tan, Lingqi Yu, Yangjian Chi, Jianping Chen, Xiaohui Fan, Xiaoyan Lu   +7 more
doaj   +1 more source

Design of a Novel and Potent Multi-Epitope Chimeric Vaccine against Human Papillomavirus (HPV): An Immunoinformatics Approach [PDF]

, 2023
Muhammad Shahab, Dejia Guo, Guojun Zheng, Yening Zou   +3 more
openalex   +1 more source

Design of a multi-epitope vaccine against goatpox virus using an immunoinformatics approach

Frontiers in Cellular and Infection Microbiology
Introduction Goatpox, a severe infectious disease caused by goatpox virus (GTPV), leads to enormous economic losses in the livestock industry. Traditional live attenuated vaccines cause serious side effects and exist a risk of dispersal. Therefore, it is
Qinqin Long, Min Wei, Yuting Wang, Feng Pang   +3 more
semanticscholar   +1 more source

Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities

Advanced Science, EarlyView.
This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao, Lifeng Liang, Ling Yang, Chunyu Lyu, Yang Lyu, Weijun Yang, Jiaran Shi, Wei Wei, Jiahui Cheng, Xiaolei Sun, Xian Zhu, Chao Chen, Xiaoting Xu, Jianchuang Qi, Wenli Li, Yizhe Zhang, Xiao Zhang, Yan Zhou, Aiqiang Dong, Juntao Chen, Bo Li, Kun Yang   +21 more
wiley   +1 more source

Current strategies, advances, and challenges in multi-epitope subunit vaccine development for African swine fever virus

Veterinary Integrative Sciences
African Swine Fever (ASF), a highly contagious and lethal viral disease affecting swine populations, presents a critical global threat with no approved vaccine.
Ella Mae Joy S. Sira, Edward C. Banico, Lauren Emily Fajardo, Nyzar Mabeth O. Odchimar, Alea Maurice Simbulan, Fredmoore L. Orosco   +5 more
doaj   +1 more source

A novel mRNA multi-epitope vaccine of Acinetobacter baumannii based on multi-target protein design in immunoinformatic approach

BMC Genomics
Acinetobacter baumannii is a gram-negative bacillus prevalent in nature, capable of thriving under various environmental conditions. As an opportunistic pathogen, it frequently causes nosocomial infections such as urinary tract infections, bacteremia ...
Yizhong Xu, Fei Zhu, Ziyou Zhou, Shiyang Ma, Peipei Zhang, Caixia Tan, Yuying Luo, Rongliu Qin, Jie Chen, Pinhua Pan   +9 more
semanticscholar   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

In silico design of Mycobacterium tuberculosis multi-epitope adhesin protein vaccines

Heliyon
Mycobacterium tuberculosis (Mtb) adhesin proteins are promising candidates for subunit vaccine design. Multi-epitope Mtb vaccine and diagnostic candidates were designed using immunoinformatic tools. The antigenic potential of 26 adhesin proteins were determined using VaxiJen 2.0. The truncated heat shock protein 70 (tnHSP70), 19 kDa antigen lipoprotein
Koobashnee Pillay, Thamsanqa E. Chiliza, Sibusiso Senzani, Balakrishna Pillay, Manormoney Pillay   +4 more
openaire   +3 more sources

Bacteriophage‐Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery

Advanced Science, EarlyView.
We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta, Mette Galsgaard Malle, Emily Tsang, Marjan Omer, Mads K. Skaanning, Sarah Youssef, Jørgen Kjems, Kurt V. Gothelf   +7 more
wiley   +1 more source