Results 191 to 200 of about 79,223 (384)

Reverse vaccinology and immunoinformatics approach to design a chimeric epitope vaccine against Orientia tsutsugamushi

Heliyon
Scrub typhus is a vector-borne infectious disease caused by Orientia tsutsugamushi and it is reportedly associated with up to 20 % of hospitalized cases of febrile illnesses.
Anutee Dolley, Himanshu Ballav Goswami, Dikshita Dowerah, Upalabdha Dey, Aditya Kumar, Vanlal Hmuaka, Rupak Mukhopadhyay, Debasree Kundu, George M. Varghese, Robin Doley, Ramesh Chandra Deka, Nima D. Namsa   +11 more
doaj   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Designing a highly immunogenic multi epitope based subunit vaccine against Bacillus cereus

, 2021
Muhammad Asif Rasheed, Muhammad Awais, Adil Aldhahrani, Fayez Althobaiti, Alaa Alhazmi, Sobia Sattar, Umara Afzal, Hosam Ali Baeshen, Hesham Ali El Enshasy, Daniel Joe Dailin, Ameena A. AL-surhanee, Faryal Kabir   +11 more
openalex   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Contriving a novel multi-epitope subunit vaccine from Plasmodium falciparum vaccine candidates against malaria [PDF]

Collins Ojonugwa Mamudu, Franklyn Nonso Iheagwam, Titilope M. Dokunmu, Esther Okafor, Olubanke Olujoke Ogunlana   +4 more
openalex   +1 more source

Multi-epitope Melanoma Peptide Vaccine [PDF]

, 2020
openaire   +1 more source

Multi-epitope peptide vaccines against human Leishmaniasis

, 2019
Leishmaniasis is a neglected tropical disease with a significant impact on human health because of the frequency and the severity of some of their clinical forms. In the absence of effective human vaccines, chemotherapy remains the major tool for the control of leishmaniasis, despite serious side effects and resistance to treatment.
openaire   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Structural Analysis of Avian Encephalomyelitis Virus Polyprotein for Development of Multi Epitopes Vaccine Using Immunoinformatics Approach

, 2021
Fatima Khalid Elhassan, Yassir A. Almofti, Khoubieb Ali Abd-elrahman, Mashair A. A. Nouri, Elsideeq E. M. Eltilib   +4 more
openalex   +2 more sources

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source