Results 341 to 350 of about 79,223 (384)

A candidate multi‐epitope vaccine against Lumpy skin disease

Transboundary and Emerging Diseases, 2022
Lumpy skin disease (LSD) is a fulminant infectious disease that mostly affects cattle and causes considerable economic loss throughout the globe. This study was conducted to develop a new multi-epitope-based vaccine against LSD that can elicit immunological responses using an in silico reverse vaccinology approach.
Md Bashir Uddin, Fatema Yeasmin Tanni, Syeda Farjana Hoque, Emran Hossain Sajib, Md Atik Faysal, Md Anisur Rahman, Asaduzzaman Galib, Ahsan Al Emon, Md Mukter Hossain, Mahmudul Hasan, Syed Sayeem Uddin Ahmed   +10 more
openaire   +2 more sources

Multi epitope vaccine candidate design against Streptococcus pneumonia

Journal of Biomolecular Structure and Dynamics, 2023
Streptococcus pneumonia, the causative agent of sepsis, meningitis and pneumonia, is held responsible for causing invasive diseases predominantly in children along with adults from both developing and developed countries. The available vaccines coverage in the context of different serotypes is limited and emergence of non-vaccine serotypes could ...
Yogeshwar, Devarakonda, M V N Janaradhan, Reddy, R S, Neethu, Aneesh, Chandran, Kirtimaan, Syal   +4 more
openaire   +2 more sources

Design of multi-epitope, analogue-based cancer vaccines

Expert Opinion on Biological Therapy, 2003
The current objective of our cancer programme is to develop an effective vaccine based on rationally designed T cell epitope analogues, for use in the adjuvant setting for non-small cell lung cancer (NSCLC) and colon cancer. Analogue epitopes, enhanced for either human leukocyte antigen (HLA) binding or T cell receptor (TCR) signalling, have been shown
John D, Fikes, Alessandro, Sette
openaire   +2 more sources

Designing a Multi-epitope Vaccine against the SARS-CoV-2 Variant Based on an Immunoinformatics Approach.

Current Computer - Aided Drug Design, 2023
BACKGROUND SARS-CoV-2 is a life-threatening virus in the world. Scientific evidence indicates that this pathogen will emerge again in the future. Although the current vaccines have a pivotal role in the control of this pathogen, the emergence of new ...
Ibrahim Farhani, A. Yamchi, Hamid Madanchi, Vahid Khazaei, M. Behrouzikhah, Hamidreza Abbasi, Mohammad Salehi, Nilufar Moradi, Samira Sanami   +8 more
semanticscholar   +1 more source

Computational design of a multi-epitope vaccine candidate against Langya henipavirus using surface proteins

Journal of Biomolecular Structure and Dynamics, 2023
In July 2022, Langya henipavirus (LayV) was identified in febrile patients in China. There is currently no approved vaccine against this virus. Therefore, this research aimed to design a multi-epitope vaccine against LayV using reverse vaccinology.
Sajjad Ahmad, Shahin Nazarian, Akram Alizadeh, Maryam Pashapour Hajialilou, Shahram Tahmasebian, M. Alharbi, A. Alasmari, Ali Shojaeian, Mahdi Ghatrehsamani, Muhammad Irfan, Hamidreza Pazoki-Toroudi, Samira Sanami   +11 more
semanticscholar   +1 more source

Computationally designed multi-epitope vaccine construct targeting the SARS-CoV-2 spike protein elicits robust immune responses in silico

Scientific Reports
Our research is driven by the need to design an advanced multi-epitope vaccine construct (MEVC) using the S-protein of SARS-CoV-2 to combat the emergence of new variants.
V. Deepthi, Aswathy Sasikumar, K. Mohanakumar, U. Rajamma   +3 more
semanticscholar   +1 more source

Multi‐epitope DNA vaccines

Immunology & Cell Biology, 1997
The evolution of vaccine strategies has seen a move from whole organisms to recombinant proteins, and further towards the ultimate in minimalist vaccinology, the epitope. The epitope‐based approach is clearly compelling as only a relatively tiny, but immunologically relevant, sequence is often capable of inducing protective immunity against a large and
openaire   +2 more sources

Vaccinomics approach for developing multi-epitope peptide pneumococcal vaccine

Journal of Biomolecular Structure and Dynamics, 2019
Streptococcus pneumoniae is a leading cause of some diseases such as pneumonia, sepsis, and meningitis mostly in children less than 5 years of age. Presently, two types of pneumococcal vaccine are available on the market: polysaccharide vaccines (PPV) that are based on capsular polysaccharides of at least 92 different serotypes, and protein-conjugated ...
Hesam Dorosti, Mahboobeh Eslami, Manica Negahdaripour, Mohammad Bagher Ghoshoon, Ahmad Gholami, Reza Heidari, Ali Dehshahri, Nasrollah Erfani, Navid Nezafat, Younes Ghasemi   +9 more
openaire   +2 more sources

Immunoinformatics-driven design of a multi-epitope vaccine targeting neonatal rotavirus with focus on outer capsid proteins VP4 and VP7 and non structural proteins NSP2 and NSP5

Scientific Reports
Rotaviral gastroenteritis remains a major global health concern, particularly for infants and young children under five years old. Prior to the introduction of the WHO-prequalified rotavirus vaccine, rotavirus (RV) was responsible for approximately 800 ...
Arijit Das Sharma, Jorge Samuel Leon Magdaleno, Himanshu Singh, Andrés Felipe Cuspoca Orduz, L. Cavallo, Mohit Chawla   +5 more
semanticscholar   +1 more source

Development of a multi-epitope vaccine from outer membrane proteins and identification of novel drug targets against Francisella tularensis: an In Silico approach

Frontiers in Immunology
Background Francisella tularensis is a category A potential thread agent, making the development of vaccines and countermeasures a high priority. Therefore, identifying new vaccine candidates and novel drug targets is essential for addressing this ...
Safoura Moradkasani, S. Esmaeili, M. A. Asadi Karam, E. Mostafavi, Behzad Shahbazi, Amir Salek Farrokhi, Mohsen Chiani, F. Badmasti   +7 more
semanticscholar   +1 more source