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Immunoplacental therapy, a potential multi-epitope cancer vaccine
Medical Hypotheses, 2006The field of tumor immunology has made great advancements in recent years. A retrospective analysis of previous vaccine strategies combined with present knowledge may provide additional insight in this treatment modality. This article provides a review of immunoplacental therapy (IPT), a cancer vaccine consisting of chorionic villi extractions from the
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Developing a multi-epitope vaccine against Helicobacter Pylori
Human ImmunologyHelicobacter pylori, a significant factor in the development of gastric cancer and peptic ulcers, poses challenges for drug development due to its resilience. Computational approaches offer potential solutions for effective vaccine development targeting its antigens while ensuring stability and safety.
Pedram Asadi, Sarabi +4 more
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Frontiers in Immunology
Human rhinovirus C (HRV-C) is a significant contributor to respiratory tract infections in children and is implicated in asthma exacerbations across all age groups. Despite its impact, there is currently no licensed vaccine available for HRV-C.
T. I. Mamun +11 more
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Human rhinovirus C (HRV-C) is a significant contributor to respiratory tract infections in children and is implicated in asthma exacerbations across all age groups. Despite its impact, there is currently no licensed vaccine available for HRV-C.
T. I. Mamun +11 more
semanticscholar +1 more source
Investigation toward multi‐epitope vaccine candidates using native chemical ligation
Peptide Science, 2008AbstractWe applied native chemical ligation (NCL) method to the synthesis of highly pure lipid‐core peptide (LCP) vaccines to attach various peptide epitopes. In the case of the synthesis of LCP vaccine with two different peptide epitopes, LCP moieties having two free Cys and two protected Cys derivatives (S‐acetamidemethyl‐Cys, (Cys(Acm)), N ...
Yoshio, Fujita +4 more
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Biologicals, 2001
We have developed efficient methods for epitope identification and vaccine design. Our process for epitope selection based on the combined use of motif analyses, binding assays and immunogenicity evaluations is described. We also describe how the projected population coverage and vaccine design can be optimized.
A, Sette +7 more
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We have developed efficient methods for epitope identification and vaccine design. Our process for epitope selection based on the combined use of motif analyses, binding assays and immunogenicity evaluations is described. We also describe how the projected population coverage and vaccine design can be optimized.
A, Sette +7 more
openaire +2 more sources
The multi-epitope polypeptide approach in HIV-1 vaccine development
Genetic Analysis: Biomolecular Engineering, 1999The application of a preventive HIV vaccine is the only hope for most developing countries to halt the AIDS pandemic. A project aimed to develop a preventive AIDS vaccine is being carried out since 1992 by three Cuban research institutions: Centro de Ingeniería Genética y Biotecnologia de La Habana, Instituto de Medicina Tropical 'Pedro Kouri' and ...
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Designing spatial and temporal control of vaccine responses
Nature Reviews Materials, 2021Shih Hao Ou, Wei Luo, Bali Pulendran
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COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials
Nature Reviews Clinical Oncology, 2021Aakash Desai +2 more
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[Multi-epitope DNA vaccines against avian influenza in chickens].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2010Multiple epitopes from one or more viruses can be lined up and co-expressed in one vector to generate multi-epitopes DNA vaccines. In the study, four recombinant plasmids were constructed based on HA and NP gene of avian influenza virus (AIV) (H5N1): (1) pIRES/HA, carrying the complete HA gene; (2) pIRES/tHA, carrying a truncated HA gene fragment of ...
Jin-Mei, Peng +3 more
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Emerging concepts in the science of vaccine adjuvants
Nature Reviews Drug Discovery, 2021Bali Pulendran, Prabhu S Arunachalam
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