Results 41 to 50 of about 38,382 (244)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Automatic Complex Function Discovery based on Multi Expression Gene Programming
工程科学与技术, 2008 :For complex function mining, traditional gene expression programming (GEP) needs large number of evolutionary generations and may plunge into local optimum.
Dai Shu-cheng, TANG Chang-jie, 朱明放
doaj
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Modeling mechanical properties of multi-components composites using a TV-GEP method
Journal of Materials Research and Technology, 2022 An improved Gene Expression Programming (GEP) by Total Variation (TV) method is introduced in this paper for modeling mechanical properties of multi-components.
Jun Wu +4 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Case Studies in Construction MaterialsPolypropylene fiber-reinforced rubberized concrete (PP-FRC) is emerging as a promising material for sustainable construction due to its improved mechanical behavior and environmental benefits, particularly through the inclusion of recycled crumb rubber ...
Ahmed A. Alawi Al-Naghi +5 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
ESOP Expression Minimization for Multi-Valued Functions Using Nonlinear Integer Programming
MathematicsThe minimization of Exclusive-OR Sum-of-Products (ESOP) expressions in the case of multi-valued input, multi-output binary, and certain types of multi-valued output functions (MVESOP) is approached in this work through a novel nonlinear integer ...
George Papakonstantinou +1 more
doaj +1 more source
IEEE Access, 2019 Nowadays, real-time scheduling is one of the key issues in cyber-physical system. In real production, dispatching rules are frequently used to react to disruptions.
Yong Zhou, Jian-Jun Yang, Lian-Yu Zheng
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source