Results 41 to 50 of about 23,971,633 (156)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Research progress on non-uniform deformation effects of slopes and instability mechanisms of key bearing bodies

Zhongguo dizhi zaihai yu fangzhi xuebao
The failure of slopes containing key bearing bodies often leads to catastrophic consequences, and the study of their instability mechanisms and prediction and early warning has become a current academic hotspot. From the perspective of the deformation of
Miaomiao WANG, Hui XU, Xiaohua PAN, Pei LI, Qiang SUN, Jing HAN, Zhijun ZHOU   +6 more
doaj   +1 more source

Non-linear curvature perturbation in multi-field inflation models with non-minimal coupling [PDF]

Journal of Cosmology and Astroparticle Physics, 2013
Using the δN formalism we consider the non-linear curvature perturbation in multi-field models of inflation with non-minimal coupling. In particular, we focus on the relation between the δN formalism as applied in the conformally related Jordan and Einstein frames.
White, Jonathan, Minamitsuji, Masato, Sasaki, Misao   +2 more
openaire   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Temperature Field Simulation Analysis of Common Rail Injector Based on Multi-Field Coupling

, 2019
: The reliability of high pressure common rail injector depends on the calculation accuracy of its temperature changing. Due to the temperature measurement limitation and difficulty, in order to obtain more detailed temperature distribution, a coupling
An, Qingsong, Chen, Guibing, Chen, Yutao, Zhang, Mingrui, Long, Zhengwei, Wang, Zuoqun   +5 more
core   +1 more source

Analyzing of Multi Field Coupling Borehole Collapse Time for Shale [PDF]

, 2017
Based on the theory of semi-permeable diaphragm equivalent pore pressure, the fluid-chemistry coupling diffusivity equation of pore pressure is deduced, and then fluid-solid-chemistry coupling model for porous media is founded.
MIAO, Xiqiang
core   +1 more source

Study on ice phase change prediction model for transmission lines based on multiphysics coupling

Scientific Reports
The accuracy of predicting ice phase changes on transmission lines is influenced by the interaction of various meteorological factors. However, existing models, which ignore the interactions between multiple physical fields, result in insufficient ...
Yingbo Pei, Qingbin Wang, Liang Wang, Shuai Zuo, Hui Zhang, Lantao Jing   +5 more
doaj   +1 more source

Multi-Granularity Modeling Method for Effectiveness Evaluation of Remote Sensing Satellites

Remote Sensing, 2023
The effectiveness indicator system of remote sensing satellites includes various satellites capabilities. Effectiveness evaluation is the process of calculating these indicators in the digital world, involving many different physical parameters of ...
Ming Lei, Yunfeng Dong
doaj   +1 more source

Size-Dependent and Multi-Field Coupling Behavior of Layered Multiferroic Nanocomposites

, 2019
The prediction of magnetoelectric (ME) coupling in nano-scaled multiferroic composites is significant for nano-devices. In this paper, we propose a nonlinear multi-field coupling model for ME effect in layered multiferroic nanocomposites based on the ...
Yang Shi, Yongkun Wang
core   +1 more source