Results 61 to 70 of about 784,718 (264)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Image Reconstruction by Frequency Extrapolation and Deep Learning in Three-Layer Medium

Mathematics
This paper proposes a novel multi-frequency extended Deep Learning (DL) model for electromagnetic image reconstruction under Transverse Magnetic (TM) wave incidence in layered media, inspired by conventional microwave imaging techniques that combine ...
Chien-Ching Chiu, Po-Hsiang Chen, Guan-Jang Li, Eng Hock Lim   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Multi-Frequency Based Direction-of-Arrival Estimation for 2q-Level Nested Radar & Sonar Arrays

Sensors, 2018
Direction finding is a hot research area in radar and sonar systems. In the case of q ≥ 2, the 2qth-order cumulant based direction of arrival (DOA) estimation algorithm for the 2q-level nested array can achieve high resolution performance.
Hao Zhou, Guoping Hu, Junpeng Shi, Ziang Feng   +3 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Fusion of Arctic sea ice drift results from multi-frequency and multi-polarization AMSR2 data using a random forest approach

International Journal of Digital Earth
Accurate monitoring of sea ice drift has become increasingly crucial for climate research and safe navigation in polar regions. Existing sea ice drift extraction methods based on passive microwave data utilize single-frequency data, which have ...
Peng Jiang, Tiantian Feng, Yushi Yang, Xiaomin Liu, Tong Hao   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Hyperspectral and Radar Airborne Imagery over Controlled Release of Oil at Sea

Sensors, 2017
Remote sensing techniques are commonly used by Oil and Gas companies to monitor hydrocarbon on the ocean surface. The interest lies not only in exploration but also in the monitoring of the maritime environment.
Sébastien Angelliaume, Xavier Ceamanos, Françoise Viallefont-Robinet, Rémi Baqué, Philippe Déliot, Véronique Miegebielle   +5 more
doaj   +1 more source