Results 161 to 170 of about 20,687 (298)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

A bi-objective robust fuzzy programming model to configure a microgrid-based cement supply chain. [PDF]

Sci Rep
Tirkolaee EB, Golpîra H, Bahramara S, Javanmardan A.   +3 more
europepmc   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

Integer linear programming for contrasting state interventions in Boolean networks. [PDF]

PeerJ
Bampos C, Megalooikonomou V.
europepmc   +1 more source

The Optimization of Industrial Structure Under the ‘Dual Carbon’ Goal via Multi-Objective Programming Model: Evidence from Guangdong Province, China [PDF]

Jing Cheng, Changhong Cai
openalex   +1 more source

His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models

Advanced Science, EarlyView.
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li, Tianqi Su, Bin Zhang, Wenkai Han, Sibin Zhang, Guiyin Sun, Yuwei Cong, Xin Chen, Jiping Qi, Yujie Wang, Shiguang Zhao, Hongxue Meng, Peng Liang, Xin Gao   +13 more
wiley   +1 more source

BGSE-RRT*: A Goal-Guided and Multi-Sector Sampling-Expansion Path Planning Algorithm for Complex Environments. [PDF]

Sensors (Basel)
Yue W, Li X, Liu Z, Jiang X, Pan L.
europepmc   +1 more source

Fuzzy Goal Programming to Optimization the Multi-Objective Problem [PDF]

, 2014
Lotfi Azzabi
openalex   +1 more source

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, EarlyView.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

A New Ant Colony Optimization-Based Dynamic Path Planning and Energy Optimization Model in Wireless Sensor Networks for Mobile Sink by Using Mixed-Integer Linear Programming. [PDF]

Biomimetics (Basel)
Chen F, Wu X, Wang Z, Qi W, Li P.
europepmc   +1 more source