Results 171 to 180 of about 3,539,790 (303)

Integrating multi-omics technologies to decipher microbiome functions. [PDF]

Nat Commun
Van Den Bossche T, Lazau EA, Aho VTE, Alfredo Blakeley-Ruiz J, Wolf M, Kunath BJ, Valentin-Alvarado LE, Hellwig P, Verschaffelt P, Rajczewski AT, Henderickx JGE, Suomi T, Xian F, Shah S, Martens L, Benndorf D, Damare SR, Haak BW, Haange SB, Piehowski PD, Kupczok A, Figeys D, Mesuere B, Palmblad M, Hettich RL, Elo LL, Vizcaíno JA, Garg N, Wang Z, Arıkan M, McCue LA, Griffin TJ, Clerbaux LA, Heyer R, Medema MH, Matallana-Surget S, Gomez-Varela D, Muth T, Tillett B, Armengaud J, Finn RD, Wilmes P, Gregory Caporaso J, Grenga L, Jagtap PD.   +44 more
europepmc   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Multi-omics integration of proteomics and metabolomics in pediatric health and disease. [PDF]

Commun Med (Lond)
Matusa AM, Tweddell D, Daley M, O'Gorman DB, Fraser DD.   +4 more
europepmc   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

The impact of multi-omics in medicine

Cell Reports Medicine
Linghua Wang, Jing Qu, Oscar Harari, Justin A. Boddey, Zhang Wang, Suvi Linna-Kuosmanen   +5 more
openaire   +3 more sources

Disentangling Heterogeneous Molecular Networks for Multi-Omics-Driven Cancer Driver Discovery. [PDF]

Adv Sci (Weinh)
Gong X, Li J, Su M, Yu P, Ma T, Zhai R, Zhang C, Zhang M, Zhang Y.   +8 more
europepmc   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Beyond the variant: hereditary cancer awareness in the multi-omics era. [PDF]

Hereditas
Kazi JU, Massoumi R.
europepmc   +1 more source

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source

Methodological Considerations Regarding the Biliary Multi-Omics Landscape: Comments on the Biliary Multi-Omics Landscape Integrating Microbiome and Metabolomics in Gallbladder Carcinogenesis. [PDF]

J Gastroenterol Hepatol
Naz A, Saqib MH, Nadeem U.
europepmc   +1 more source