Results 201 to 210 of about 3,539,790 (303)

From molecules to minds: Integrative multi-omics in psychiatry. [PDF]

J Mood Anxiety Disord
Abbasi H, Hawn SE, Javanbakht A, Seedat S, Bourassa K, Sinnott SM, Seligowski AV, Hemmings S, Kimbrel NA, Wolf E, Smith AK, Brick L, Mehta D.   +12 more
europepmc   +1 more source

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi-Omics Data. [PDF]

Adv Sci (Weinh)
Ge Y, Zhang F, Liu Y, Jiang C, Gao P, Tan NS, Zhang S, Shen Y, Zhou Q, Zhou X, Wang X, Zhao F, Wang C, Shen X.   +13 more
europepmc   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

Multi-omics Investigations of Immune Microenvironment of Human Colorectal Cancer. [PDF]

Cancer Genomics Proteomics
Zeng H, Lin L, Chen Y, Xia L, Tang D, Dai Y, Zhang W.   +6 more
europepmc   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Multi-Omics Comes of Age: Immune Profiling of Human Aging. [PDF]

Immunol Cell Biol
Hicks KS, Jackaman C.
europepmc   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Consistency of feature attribution in deep learning architectures for multi-omics. [PDF]

Sci Rep
Claborne D, Flores J, Erwin S, Durell L, Degnan D, Richardson R, Fore R, Bramer L.   +7 more
europepmc   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Integrative multi-omics and bioinformatic analysis of <i>MMP20</i> in amelogenesis imperfecta. [PDF]

Jpn Dent Sci Rev
Leban T, Kunej T.
europepmc   +1 more source