Results 211 to 220 of about 6,133,638 (273)

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Calibrated, cost-sensitive, explainable ensemble learning for customer churn prediction in retail banking: a leakage-safe pipeline and single-dataset case study. [PDF]

Front Artif Intell
Karim F, Alam MI, Lalafaryan A, Mkrtchyan A, Hovakimyan A, Mustafizur M, Alam GT, Manik MMTG.   +7 more
europepmc   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

The application of deep neural networks to the detection of lumbar hernias: results from the approaches based on convolutional networks and transformers. [PDF]

Front Radiol
Fernandes A, Rodriguez JPM, Moleirinho S, Trofimenko I, Guseva E, Martinovich A, de Oliveira Morais IM, Bisolo L, Mendes Gomes L, Machado J.   +9 more
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Design of a low-power RISC-V based intelligent endoscopy detection processor: EndoRISC-V. [PDF]

Sci Rep
Anand A, B S, P S, A AA.
europepmc   +1 more source

YOLO12 Down Feather Quality Classification Method Based on A2C2f-CGLU Feature Enhancement. [PDF]

Sensors (Basel)
Fan Z, Jing S, Tong L, Sun X.
europepmc   +1 more source

An integrated fuzzy multi-criteria decision making and mixed-integer linear programming optimization framework for project risk assessment and response strategy selection: A case study of a liquefied petroleum gas pipeline construction project. [PDF]

PLoS One
Senisel Bachari M, Khademvatani A, Iranfar M.   +2 more
europepmc   +1 more source

A methodological framework for real-world performance studies of clinical variant classification platforms at early organizational stages. [PDF]

Front Genet
Mitev V.
europepmc   +1 more source