BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Multi-scale modelling of biomass pyrolysis process
, 2014 In this work, a phenomenological model has been developed for examining the particle scale degradation of biomass. Furthermore, a Computational Fluid Dynamics (CFD) model has been developed to study the mixing/segregation behaviour of biomass with other ...
Abhishek Sharma (144862)
core
Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1
FEBS Open Bio, EarlyView.The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn +2 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Surfactant-Mediated Airway and Acinar Interactions in a Multi-Scale Model of a Healthy Lung. [PDF]
Front Physiol, 2020 Ma H, Fujioka H, Halpern D, Gaver DP.
europepmc +1 more source
Concurrent multi-scale modeling of structures and damage analyses
, 2007 The methodology and strategy for concurrent multi-scale modeling of large structures such as long span bridges were studied in order to perform the multi-scale numerical analysis on structural, dynamic response and local damage.
Li, Z.X. +4 more
core
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
A multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth. [PDF]
Sci Rep, 2020 Nikmaneshi MR +3 more
europepmc +1 more source
Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen +11 more
wiley +1 more source
Turbulence drives arteriovenous remodeling: an experimentally validated multi-scale model of neointimal hyperplasia. [PDF]
Phys Med BiolVarsanik MA +8 more
europepmc +1 more source