Results 81 to 90 of about 1,950,051 (253)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Grid codes vs. multi-scale, multi-field place codes for space

Frontiers in Computational Neuroscience
IntroductionRecent work on bats flying over long distances has revealed that single hippocampal cells have multiple place fields of different sizes.
Robin Dietrich, Robin Dietrich, Nicolai Waniek, Nicolai Waniek, Martin Stemmler, Alois Knoll   +5 more
doaj   +1 more source

Design of a Multi-Scale Long-Focal Imaging System Based on Tessar Primary Lenses [PDF]

Hangkong bingqi
In order to meet the demand for accurate identification of distant targets by improving the resolution of multi-scale imaging systems, from primary lenses focus, a design scheme of a multi-scale long-focal imaging system based on the Tessar primary ...
Liu Fei, Tai Zhichao, Zhang Minjie, Xiang Meng, Yu Chun, Shao Xiaopeng
doaj   +1 more source

Application of Multi-Objective Evolutionary Optimization Algorithms to Reactive Power Planning Problem [PDF]

, 2008
This paper presents a new approach to treat reactive power (VAr) planning problem using multi-objective evolutionary algorithms. Specifically, Strength Pareto Evolutionary Algorithm (SPEA) and Multi-Objective Particle Swarm Optimization (MOPSO ...
Mehdi, Eghbal, Yorino, Naoto, Zoka, Yoshifumi   +2 more
core  

Multi-scale optimization of the design of offshore wind farms

Applied Energy, 2022
Davide Cazzaro, Alessio Trivella, F. Corman, David Pisinger   +3 more
semanticscholar   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

A variational expectation-maximization framework for balanced multi-scale learning of protein and drug interactions

Nature Communications
Protein functions are characterized by interactions with proteins, drugs, and other biomolecules. Understanding these interactions is essential for deciphering the molecular mechanisms underlying biological processes and developing new therapeutic ...
Jiahua Rao, Jiancong Xie, Qianmu Yuan, Deqin Liu, Zhen Wang, Yutong Lu, Shuangjia Zheng, Yuedong Yang   +7 more
doaj   +1 more source

Multi-scale search for black-box optimization : theory & algorithms [PDF]

, 2020
This thesis focuses on a special class of MP algorithms for continuous black-box optimization. Black-box optimization has been a recurrent subject of interest for decades, as many real-world applications can be modeled as black-box optimization problems.
openaire   +2 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Contribution-Driven Task Design: Multi-Task Optimization Algorithm for Large-Scale Constrained Multi-Objective Problems

Computers
Large-scale constrained multi-objective optimization problems (LSCMOPs) are highly challenging due to the need to optimize multiple conflicting objectives under complex constraints within a vast search space.
Huai Li, Tianyu Liu
doaj   +1 more source