Results 91 to 100 of about 387,938 (287)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Adapting Object Detection Models for Multi-Target Detection Utilizing Radars

open access: yesALKÜ Fen Bilimleri Dergisi
This paper investigates the use of Deep Learning (DL) in multiple input multiple output (MIMO) radar target detection, focusing on azimuth and elevation estimation. Traditional methods face challenges like interference and reflections, especially in multi-target scenarios. Feature extraction conventionally relies on range correlation, Doppler filtering,
İbrahim Rıza Hallaç   +4 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Detection Aided Multi-Filter Target Tracking Algorithm

open access: yesIEEE Access, 2019
When the target is partially occluded or undergoes drastic appearance change, drift is prone to occur in traditional correlation filter-based trackers and ultimately leads to tracking failure. This paper proposes a robust tracking algorithm, which can be
Yue Min, Zhenzhong Wei, Ke Tan
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

open access: yesFEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez   +5 more
wiley   +1 more source

LDSI-YOLOv8: Real-Time Detection Method for Multiple Targets in Coal Mine Excavation Scenes

open access: yesIEEE Access
To address challenges such as missed detection and low recognition rates in multi-target detection within coal mining excavation scenes, attributed to factors like low illumination, high dust and fog, multi-target occlusion and large target scale spans ...
Zhihao Zhang   +5 more
doaj   +1 more source

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