Results 81 to 90 of about 69,929 (304)

An extension of the Jacobi algorithm for multi-valued mixed complementarity problems

, 2020
We consider a generalized mixed complementarity problem (MCP) with box constraints and multi-valued cost mapping. We introduce a concept of an upper Z-mapping, which generalizes the well-known concept of the single-valued Z-mapping and involves the ...
Konnov I.
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Fixed point theorems for extended interpolative multi-valued non-self mappings in b-metric space with some application

European Journal of Mathematics and Applications, 2023
The study of fixed point theorems for multi-valued non-self mappings on metrically convex metric space was initiated by Assad and Kirk. In this paper, we will prove and extend the fixed point results for an extended interpolative multivalued non-self ...
Lucas Wangwe
doaj  

Viscosity approximation methods for a nonexpansive multi-valued mapping in CAT (0) spaces and variational inequality

, 2020
The purpose of this paper is to introduce the nonexpansive multivalued mapping in CAT (0) spaces. The convexity and closednes of a fixed point set of such mapping and demiclosed principle for such mapping are also studied.
Hong Liu, Yi, Li Bo
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

ON GUARANTEED RESULT IN GAME PROBLEMS OF CONTROLLED OBJECTS APPROACH

Міжнародний науково-технічний журнал "Проблеми керування та інформатики"
The problem of a guaranteed result in game problems of approach of controlled objects is considered. A method is proposed for solving such problems associated with the construction of some scalar functions that qualitatively characterize the course of ...
Й.С. Раппопорт
doaj   +1 more source

Some fixed point results for a class of g-monotone increasing multi-valued mappings

, 2013
In this paper, we introduce the new notion of g-monotone mapping and prove some fixed point theorems for multi-valued and single-valued g-increasing mappings in partially ordered metric spaces. The mappings considered in this paper are assumed to satisfy
Guo, Ting, Yin, Jiandong
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source