Results 131 to 140 of about 3,233,192 (305)

Reliable Multi-View Clustering [PDF]

, 2018
With the advent of multi-view data, multi-view learning (MVL) has become an important research direction in machine learning. It is usually expected that multi-view algorithms can obtain better performance than that of merely using a single view. However,
Liu, Tongliang, Yi, Dongyun, Tao, Hong, Hou, Chenping, Liu, Xinwang, Zhu, Jubo   +5 more
core   +1 more source

One-step Multi-view Clustering Based on Diversity and Consistency [PDF]

Jisuanji gongcheng
With the development of data collection technology, multi-view data have become increasingly common. Compared to single-view data, multi-view data contain richer information, which is usually characterized by consistency and diversity information.
HU Aoran, CHEN Xiaohong
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Fast Multi-View Outlier Detection via Deep Encoder [PDF]

, 2020
Multi-view outlier detection has been well investigated in recent years. However, 1) most existing methods cannot efficiently handle outlier detection problem for large-scale multi-view data, since exploring pairwise constraints among different views ...
Hou DD(侯冬冬), Li, Jun, Li, Kai, Sun G(孙干), Dong JH(董家华), Cong Y(丛杨)   +5 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Multi-view information fusion based graph collaborative filtering recommendation

Journal of King Saud University: Computer and Information Sciences
With the development of graph learning technology, different modalities of content information such as visual and textual can be learned. Applying graph learning techniques to recommendation has become a research trend.
Ruihui Mu, Xin Li, Jiying Zhang
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Explainable graph learning for multimodal single-cell data integration

BMC Bioinformatics
Background Understanding cellular heterogeneity and identifying functionally distinct subpopulations are central goals in single-cell analysis. Integrating paired multi-omic data, such as transcriptomic and proteomic profiles from the same cells, offers ...
Mehmet Burak Koca, Fatih Erdoğan Sevilgen   +1 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source