Results 31 to 40 of about 623,178 (219)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

AI-Based 3D-Segmentation Quantifies Sarcopenia in Multiple Myeloma Patients

Diagnostics
Background: Sarcopenia is characterized by a loss of muscle mass and strength, resulting in functional limitations and an increased risk of falls, injuries and fractures. The aim of this study was to obtain detailed information on skeletal muscle changes
Thuy-Duong Do, Tobias Nonnenmacher, Marieke Burghardt, Stefanie Zschaebitz, Marina Hajiyianni, Elias Karl Mai, Marc-Steffen Raab, Carsten Müller-Tidow, Hans-Ulrich Kauczor, Hartmut Goldschmidt, Ulrike Dapunt   +10 more
doaj   +1 more source

Impact of Hepatic Encephalopathy on Clinical Characteristics and Adverse Outcomes in Prospective and Multicenter Cohorts of Patients With Acute-on-Chronic Liver Diseases

Frontiers in Medicine, 2021
Importance: Hepatic encephalopathy is a severe complication, and its contribution to clinical adverse outcomes in patients with acute-on-chronic liver diseases from the East is unclear.Objective: We aimed to investigate the impact of hepatic ...
Liyuan Long, Hai Li, Hai Li, Hai Li, Guohong Deng, Guohong Deng, Xianbo Wang, Xianbo Wang, Sihong Lu, Beiling Li, Zhongji Meng, Zhongji Meng, Yanhang Gao, Yanhang Gao, Zhiping Qian, Zhiping Qian, Feng Liu, Feng Liu, Feng Liu, Xiaobo Lu, Xiaobo Lu, Haotang Ren, Jia Shang, Hai Li, Shaoyang Wang, Yubao Zheng, Yubao Zheng, Huadong Yan, Huadong Yan, Shan Yin, Shan Yin, Wenting Tan, Qun Zhang, Xin Zheng, Xin Zheng, Jinjun Chen, Jinjun Chen, Sen Luo, Jinming Zhao, Wei Yuan, Tao Li, Rongjiong Zheng, Junping Liu, Xiaoxiao Liu, Wenyi Gu, Wenyi Gu, Sumeng Li, Xue Mei, Ruochan Chen, Yan Huang, Yan Huang   +50 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Integrated aerobic exercise with LDE-docetaxel treatment: a novel approach to combat prostate cancer progression

Scientific Reports
The variability in response to conventional prostate cancer (PC) therapies, coupled with the emergent issue of drug resistance, underscores the critical need for innovative treatment strategies.
Allice Santos Cruz Veras, Victor Rogério Garcia Batista, Rafael Ribeiro Correia, Maria Eduarda de Almeida Tavares, Rafael Jesus Gonçalves Rubira, Elaine Rufo Tavares, Inês Cristina Giometti, Raul Cavalcante Maranhão, Giovana Rampazzo Teixeira   +8 more
doaj   +1 more source

Targeting Neutrophil Extracellular Traps in Neuroinflammation: A Therapeutic Perspective on Neurodegenerative Diseases

Brain Sciences
Neuroinflammation is a complex process involved in the pathogenesis of several neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, Huntington’s disease, and amyotrophic lateral sclerosis.
Iolanda Masalskiene Costa, Alexandre Kanashiro, Giovanna Siqueira Favi Barros, Ana Julia Monteiro, Caio Santos Bonilha, Giovane Galdino, Flavio Protasio Veras   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The Role of the Thalamus in Nociception: Important but Forgotten

Brain Sciences
Pain is a complex response to noxious stimuli. Upon detection of the nociceptive stimulus by first-order neurons or nociceptors, an action potential ascends to the spinal dorsal horn, a crucial site for synapsing with second-order neurons.
Giovane Galdino, Flavio Protasio Veras, Tayllon dos Anjos-Garcia   +2 more
doaj   +1 more source

Genetic Variations and Clinical Features of NPHS1-Related Nephrotic Syndrome in Chinese Children: A Multicenter, Retrospective Study

Frontiers in Medicine, 2021
Introduction: Few studies have addressed the genetic spectrum of NPHS1 variants in Chinese children with nephrotic syndrome. In this multicenter study, the clinical manifestations and features of NPHS1 variants in Chinese children with nephrotic syndrome
Liping Rong, Lizhi Chen, Jia Rao, Qian Shen, Guomin Li, Jialu Liu, Jianhua Mao, Chunyue Feng, Xiaowen Wang, Si Wang, Xinyu Kuang, Wenyan Huang, Qingshan Ma, Xiaorong Liu, Chen Ling, Rong Fu, Xiaojie Gao, Guixia Ding, Huandan Yang, Mei Han, Zhimin Huang, Qian Li, Qiuye Zhang, Yi Lin, Xiaoyun Jiang, Hong Xu   +25 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source