Results 171 to 180 of about 4,440,004 (198)

Effect of COMT and UGT1A Variants on Clinical Response to Opicapone in Parkinson's Disease

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. Symptomatic treatment is based on dopaminergic replacement. With disease progression, the initial benefit of levodopa becomes inconsistent, and motor complications emerge.
Elena Ojeda‐Lepe   +15 more
wiley   +1 more source

Proteomic Signatures of Ectopic Fat Distribution: Tissue‐Specific Drivers and Clinical Implications

open access: yesMed Research, EarlyView.
Integration of plasma proteomics and multi‐organ MRI in 666 UK Biobank participants, combined with a knockoff‐based causal inference and machine learning framework, reveals organ‐specific drivers of ectopic fat: PLA2G1B (pancreas), ERBB2/IGFBP2 (liver), CA14 (muscle), and NCAM2/TNFRSF10B (pericardium). These drivers engage distinct pathways (e.g., PI3K‐
Bing Zhang   +9 more
wiley   +1 more source

Role of Sexuality in the Quality of Life of Palliative Care Patients: A Narrative Review. [PDF]

open access: yesCureus
Díaz Chamba WI   +4 more
europepmc   +1 more source

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