Effect of COMT and UGT1A Variants on Clinical Response to Opicapone in Parkinson's Disease
Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. Symptomatic treatment is based on dopaminergic replacement. With disease progression, the initial benefit of levodopa becomes inconsistent, and motor complications emerge.
Elena Ojeda‐Lepe +15 more
wiley +1 more source
Comparison of Fatty Acid Binding Protein 3 and Ankle Brachial Index for Predicting Peripheral Artery Disease Outcomes. [PDF]
Li B +6 more
europepmc +1 more source
Proteomic Signatures of Ectopic Fat Distribution: Tissue‐Specific Drivers and Clinical Implications
Integration of plasma proteomics and multi‐organ MRI in 666 UK Biobank participants, combined with a knockoff‐based causal inference and machine learning framework, reveals organ‐specific drivers of ectopic fat: PLA2G1B (pancreas), ERBB2/IGFBP2 (liver), CA14 (muscle), and NCAM2/TNFRSF10B (pericardium). These drivers engage distinct pathways (e.g., PI3K‐
Bing Zhang +9 more
wiley +1 more source
Comparative prognostic performance of International Federation of Gynecology and Obstetrics 2023 staging system and the 2025 European Society of Gynaecological Oncology-European Society for Radiotherapy and Oncology-European Society of Pathology risk classification in endometrial cancer. [PDF]
Hong JH +4 more
europepmc +1 more source
SGLT2 Inhibition as a Perioperative Cardiorenal Stabilizer in Cardiac Surgery: Integrated Clinical Cohort and Pleiotropic Network-Based Pharmacological Analysis. [PDF]
Onar LC, Guner E, Yilmaz I.
europepmc +1 more source
Role of Sexuality in the Quality of Life of Palliative Care Patients: A Narrative Review. [PDF]
Díaz Chamba WI +4 more
europepmc +1 more source
A Brief Online Mentalization-Based Video-Feedback Intervention (VFI-RF) for Mother-Infant Interaction in Postnatal Risk Conditions: Protocol for a Multicenter Single-Arm Feasibility Study. [PDF]
Mazza C +8 more
europepmc +1 more source
Distinct Difference in the Geometries of NCCL<sup>-</sup> Anions (L = N<sub>2</sub>, CO, CS): A Balance Between π Conjugation and Steric Repulsion. [PDF]
Wei J +6 more
europepmc +1 more source
Adenocarcinoma admixed with neuroendocrine carcinoma of the cervix: a clinicopathological diagnostic study and molecular features. [PDF]
Yu M, Jiang M, Zhang X, Chen H, Ye X.
europepmc +1 more source

