Results 81 to 90 of about 1,003,545 (313)

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Rare Complications of Cervical Spine Surgery: Pseudomeningocoele. [PDF]

, 2017
STUDY DESIGN: This study was a retrospective, multicenter cohort study. OBJECTIVES: Rare complications of cervical spine surgery are inherently difficult to investigate.
Ailon, Tamir, Arnold, Paul M., Buser, Zorica, Chou, Dean, Corriveau, Mark, Fehlings, Michael G., Fish, David E., Hilibrand, Alan S., Hsu, Wellington K., Lee, Sungho, Lord, Elizabeth L L., Massicotte, Eric M., Mroz, Thomas E., Mummaneni, Praveen V., Nassr, Ahmad, Pace, Jonathan, Riew, K. Daniel, Sasso, Rick C., Sebastian, Arjun S., Shaffrey, Christopher, Smith, Gabriel A., Smith, Justin S., Smith, Zachary A., Steinmetz, Michael P., Than, Khoi D., Traynelis, Vincent C., Wang, Jeffrey C.   +26 more
core   +2 more sources

Multicenter Studies: Relevance, Design and Implementation

Indian Pediatrics, 2022
Multicenter studies are essential in clinical and public health research with several advantages compared to single-center studies. Multicenter studies are attractive and advantageous, allowing quicker recruitment, diverse population coverage and increased generalizability.
openaire   +2 more sources

Fibrinogen Changes Before and After Intravenous Thrombolysis as Predictors of Cerebral Injury and Clinical Outcomes in Acute Ischemic Stroke: A Multicenter Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma fibrinogen is essential in thrombosis and fibrinolysis, yet its dynamic changes pre‐ and post‐intravenous thrombolysis (IVT) for predicting brain injury severity and prognosis in acute ischemic stroke (AIS) patients remain unclear.
Wenhai Zhai, Yang Qu, Reziya Abuduxukuer, Kejia Zhang, Peng Zhang, Xin Tang, Huaimei Zhang, Lijuan Wang, Lichong Yang, Shuangxu Tan, Zhimei Yuan, Ce Han, Lili He, Yuping Zheng, Fenglan Zhao, Lijie Guo, Ligang Jiang, Jinfeng Li, Yongfei Jiang, Xuexia Zou, Dan Xu, Han Xu, Xiaojia Wang, Yingbin Qi, Xuefeng Hu, Yu Zhang, Zhen‐Ni Guo, Hang Jin, on behalf of the Biomarkers of Brain Injury Investigator Study Group   +28 more
wiley   +1 more source

Protocol for a Multicenter Study [PDF]

, 2017
Background: In Parkinson’s disease (PD), alpha-synuclein accumulation in cutaneous autonomic pilomotor and sudomotor nerve fibers has been linked to autonomic nervous system disturbances even in the early stages of the disease.
Arndt, Martin, Buchmann, Sylvia J., Kubasch, Anne Sophie, Lipp, Axel, Pinter, Alexandra, Siepmann, Timo, Stibal, Leonie   +6 more
core   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Outcomes of Microsurgical Resection of Low-Grade Cerebral Arteriovenous Malformations: A Prospective Observational Multicenter Study from a Low-Middle-Income Country

Brain Hemorrhages
Objective: To appraise the overall outcomes of microsurgical resection of low-grade arteriovenous malformations (AVMs) in a low-middle-income country. Methods: Data was collected prospectively from three different neurosurgical centres in Pakistan for ...
Adnan Khaliq, Ahtesham Khizar, Muhammad Hassan Raza, Muhammad Idris Khan, Nayab Gul   +4 more
doaj   +1 more source

Current evidence for treatment with nusinersen for spinal muscular atrophy : a systematic review [PDF]

, 2019
Recent discovery of nusinersen, an antisense oligonucleotide drug, has provided encouragement for improving treatment of spinal muscular atrophy. No therapeutic options currently exist for this autosomal recessive motor neuron disorder.
Meylemans, Antoon, De Bleecker, Jan
core   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

The EULAR–OMERACT rheumatoid arthritis MRI reference image atlas: the metacarpophalangeal joints [PDF]

, 2005
This paper presents the metacarpophalangeal (MCP) joint magnetic resonance images of the EULAR–OMERACT rheumatoid arthritis MRI reference image atlas. The illustrations include synovitis in the MCP joints (OMERACT RA magnetic resonance imaging scoring ...
Bird, P., Conaghan, P., Edmonds, J., Ejbjerg, B., Emery, P., Lassere, M., McQueen, F., O’Connor, P., Peterfy, C., Shnier, R., Østergaard, M.   +10 more
core   +3 more sources