Results 121 to 130 of about 1,227,058 (270)

Alcohols as Nucleophiles in Multicomponent Reactions

The direct use of abundant and inexpensive alcohols as nucleophiles in organic synthesis is inherently challenging due to the poor reactivity of the hydroxyl group.
Xinyue Dong, lele fang, Fumin Shen, Can Zhang, Zhan-Yong Wang, Xiao-Tian Wang, Ran Xia   +6 more
core   +1 more source

Piperazine scaffolds via isocyanide-based multicomponent reactions

, 2010
Piperazine scaffolds are amongst the most extensively used backbones in medicinal chemistry and many bioactive compounds are built upon this template.
Dömling, Alexander, Yijun Huang, Huang, Yijun, Alexander Dömling   +3 more
core   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Unexpected products in isocyanide-based multicomponent reactions

Isocyanide-based multicomponent reactions (I-MCRs) are among the most important synthetic methods for producing a wide range of commercial drugs, natural product analogues, pseudopeptides, and biologically active compounds.
Saeed Torabi, Mohammad Taghi Nazeri, Marzieh Norouzi, Mohammad Amin Vakili, Ahmad Shaabani, Tahereh Nasiriani   +5 more
core   +1 more source

A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers

Advanced Science, EarlyView.
Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels, Joana Caria, Edward A. Lemke   +2 more
wiley   +1 more source

Organocatalytic enantioselective multicomponent reactions (OEMCRs)

, 2007
The achieved level of expertise in organocatalytic processes has allowed synthetic chemists to apply this useful synthetic strategy to enantioselective multicomponent reactions.
Guillena, Gabriela, Diego J. Ramon, Gabriela Guillena, Yus, Miguel, Ramón, Diego J., Miguel Yus   +5 more
core   +1 more source

Hydrogen‐Bonding‐Directed Assembly of COF/Nanocluster Hybrids With Synergistic Roles for Efficient Solar Hydrogen Production

Advanced Science, EarlyView.
Hydrogen‐bonding‐directed assembly enables molecular‐level integration of a covalent organic framework and NiZnCo nanoclusters. The engineered interface couples directional charge transfer, multimetal synergy, and photothermal‐assisted catalysis, providing a versatile strategy for efficient noble‐metal‐free solar hydrogen production.
Ailing Pan, De Yan, Anwu Xu, Hong Du, Abulikemu Abudu Rexit, Gang Zhang   +5 more
wiley   +1 more source

Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction

Advanced Science, EarlyView.
Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen, Bapan Biswas, Apinya Ngoipala, Julia Wiktor, Ujjwal Pal, Shalini Singh   +5 more
wiley   +1 more source

Ugi Multicomponent Reaction

Organic Syntheses, 2017
Dömling, Alexander, Boltjes, André, Liu, Haixia, Cao, Haiping, Baker-Tripp, Emma L   +4 more
openaire   +1 more source

Reducing disruptive classroom behavior with multicomponent intervention: a literature review [PDF]

, 2002
Plan BAttention Deficit Hyperactivity Disorder (ADHD) affects children and their learning in many ways. One main educational obstacle of children ADHD is how their disruptive classroom behavior can inhibit their ability to learn.
Wille, Jessica R.
core