Results 111 to 120 of about 5,361,319 (303)

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

open access: yesAdvanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou   +12 more
wiley   +1 more source

Q‐LEAP: Millisecond Hyperdimensional Optimization for Full‐Spectrum Optical Metamaterials

open access: yesAdvanced Science, EarlyView.
Q‐LEAP integrates physics‐informed residual machine learning with factorization‐machine‐encoded quantum annealing to design full‐spectrum optical metamaterials. It explores a 2108 design space and, in a single 2.56 ms annealing step, reaches 85.83% of the theoretical FoM limit, enabling selective 5‐8 µm emission with 3–5 and 8–14 µm suppression and ∼40×
Zikang Guo   +3 more
wiley   +1 more source

On some linear two-point inverse problem for a multidimensional heat conduction equation with semi-nonlocal boundary conditions

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы
It is known that V.A. Ilyin and E.I. Moiseev studied generalized nonlocal boundary value problems for the Sturm-Liouville equation, the nonlocal boundary conditions specified at the interior points of the interval under consideration. For such problems,
С.З. Джамалов   +1 more
doaj   +1 more source

Transformer‐Based PET/CT Fusion Enables Preoperative Prediction and Prognostic Stratification of Spread Through Air Spaces in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
An eight‐stream 2.5D Transformer integrates complementary PET metabolic and CT morphologic information to estimate spread‐through‐air‐spaces risk before surgery in lung adenocarcinoma. The model generalizes across independent centers, while its continuous risk score independently stratifies progression‐free survival, supporting further prospective ...
Xin‐Yu Zhu   +7 more
wiley   +1 more source

A consistent multidimensional Pigou-Dalton transfer principle [PDF]

open access: yes
The Pigou-Dalton principle demands that a regressive transfer decreases social welfare. In the unidimensional setting this principle is consistent, because regressivity in terms of attribute amounts and regressivity in terms of individual well-being ...
Luc Lauwers   +2 more
core   +2 more sources

Efficient Algorithmic Techniques for Several Multidimensional Geometric Data Management and Analysis Problems [PDF]

open access: yesInformatică economică, 2008
In this paper I present several novel, efficient, algorithmic techniques for solving some multidimensional geometric data management and analysis problems. The techniques are based on several data structures from computational geometry (e.g. segment tree
Mugurel Ionut ANDREICA
doaj  

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

open access: yesAdvanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu   +5 more
wiley   +1 more source

Analytical Prediction of Critical Transitions in Oscillator Networks With Non‐Local Links

open access: yesAdvanced Science, EarlyView.
An analytical framework reveals how global coupling, second‐harmonic strength, noise, and network structure govern oscillator‐based Ising dynamics. Spectral reduction predicts stability boundaries, while Fokker–Planck analysis captures one‐ to two‐cluster transitions and identifies conditions favoring low‐energy configurations.
Qiang Li   +5 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

open access: yesAdvanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun   +12 more
wiley   +1 more source

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