Results 31 to 40 of about 13,579 (247)

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

The main elements of the solution to China’s demotic violence [PDF]

SHS Web of Conferences
Domestic violence represents a complex and pervasive issue within China, deeply entrenched in historical norms and sociocultural attitudes. Even with legal reforms aimed at criminalizing domestic violence and establishing legal protections for victims ...
Yin Xuan
doaj   +1 more source

Effects of Information Overload, Communication Overload, and Inequality on Digital Distrust: A Cyber-Violence Behavior Mechanism

Frontiers in Psychology, 2021
In recent years, there has been an escalation in cases of cyber violence, which has had a chilling effect on users' behavior toward social media sites.
Mingyue Fan, Yuchen Huang, Sikandar Ali Qalati, Syed Mir Muhammad Shah, Dragana Ostic, Zhengjia Pu   +5 more
doaj   +1 more source

Short version of the Multidimensional Scale of Dating Violence ( MSDV 2.0) in Spanish‐language: Instrument development and psychometric evaluation

Journal of Advanced Nursing, 2022
Abstract Aims To develop and psychometrically test the short version of the Multidimensional Scale of Dating Violence (MSDV 2.0) in Spanish‐language to detect violence perpetrated and suffered in dating relationships. Design
María de los Ángeles García‐Carpintero‐Muñoz, Lorena Tarriño‐Concejero, Eugenia Gil‐García, Ana María Pórcel‐Gálvez, Sergio Barrientos‐Trigo   +4 more
openaire   +2 more sources

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Risk factors of adolescent exposure to violence in Burkina Faso

BMC Public Health, 2022
Background Globally violence against children and adolescents is a significant public health problem. Since children rely on family for early learning and socialization, evidence of the factors associated with exposure to violence within households may ...
Ronald Musizvingoza, Nyasha Tirivayi, Frank Otchere, Francesca Viola   +3 more
doaj   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Impact of Perceived Social Support and Domestic Violence on Mental Health among Housewives

Journal of Business and Social Review in Emerging Economies, 2020
Given the noteworthy health impacts of social support and domestic violence against women, the current study was directed to research the effect of Perceived Social Support and Domestic Violence on Mental Health among house wives. Sample of the study was
Umbreen Khizer, Fatima Khurram Bukhari, Samar Fahd   +2 more
doaj  

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source