Results 71 to 80 of about 1,678,428 (311)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Increasing physician‐perceived comfort about ostomies in pediatric inflammatory bowel disease: An interprofessional quality improvement project

Learning Health Systems
Introduction Pediatric inflammatory bowel disease (IBD) is a chronic disease with various treatments, including ostomy surgery, which is associated with stigma.
Jennie G. David, Hannah McKillop, Meghan Fisher, Ashley M. Kroon Van Diest   +3 more
doaj   +1 more source

Good multiple sclerosis (MS) care and how to get there in Canada: Perspectives of Canadian healthcare providers working with persons with MS

Frontiers in Neurology, 2023
ObjectiveThe literature that has examined healthcare access and needs of the multiple sclerosis (MS) population is limited. Currently, no research has engaged healthcare providers delivering services to this population to examine their perspectives on ...
Julie Petrin, Ruth Ann Marrie, Ruth Ann Marrie, Virginia Devonshire, Draga Jichici, Olinka Hrebicek, Luanne M. Metz, Sarah A. Morrow, Jiwon Oh, Penelope Smyth, Sarah J. Donkers   +10 more
doaj   +1 more source

COVID-19: A Multidisciplinary Review

Frontiers in Public Health, 2020
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that is responsible for the 2019–2020 pandemic. In this comprehensive review, we discuss the current published literature surrounding the SARS-CoV-2 virus. We examine the
N. Chams, S. Chams, R. Badran, A. Shams, Abdallah Araji, M. Raad, S. Mukhopadhyay, E. Stroberg, E. Duval, L. Barton, I. Hajj Hussein   +10 more
semanticscholar   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Development of a Multidisciplinary Clinic for Patients with Ehlers Danlos Syndromes: Considerations and Strategies

Journal of Multidisciplinary Healthcare, 2023
William R Black,1,2 Jordan T Jones,1,3,4 Eric T Rush,1,3,4 Lindsey Malloy Walton,1,3,4 Ashley Harding5 1Department of Pediatrics, University of Kansas School of Medicine, Kansas City, KS, USA; 2Center for Children’s Healthy Lifestyles and Nutrition ...
Black WR, Jones JT, Rush ET, Malloy Walton L, Harding A   +4 more
doaj  

Using the Findings of a National Survey to Inform the Work of England’s Genomics Education Programme

Frontiers in Genetics, 2019
A national coordinated approach to workforce education and training in genomics is essential for the successful implementation of whole genome sequencing and, more broadly, genomic medicine within the National Health Service (NHS) in England.
Siobhan Simpson, Anneke Seller, Michelle Bishop   +2 more
doaj   +1 more source

Recent progress in multidisciplinary treatment for patients with esophageal cancer

Surgery today (Print), 2019
Esophageal cancer is one of the most aggressive gastrointestinal cancers. This review focuses on eight topics within the multidisciplinary approach for esophageal cancer.
Masayuki Watanabe, Reiko Otake, R. Kozuki, T. Toihata, Keita Takahashi, A. Okamura, Y. Imamura   +6 more
semanticscholar   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source