Results 171 to 180 of about 1,199,702 (267)

Assessment of Large Language Models in Colorectal Cancer Multidisciplinary Tumor Board Decision-Making: A Retrospective Single-Center Comparison of Guideline-Integrated General-Purpose vs. Domain-Specialized Models. [PDF]

Curr Oncol
Farzaliyeva A, Ramazanoglu MN, Oguz A, Altundag O, Akcali Z.   +4 more
europepmc   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Perceptions of Changes in the Operating Environment and Their Impact on Occupational Health Care Practices: A Qualitative Interview Study. [PDF]

Health Serv Insights
Nissinen S, Wallius MA, Sormunen E.
europepmc   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Current practices and challenges in the management of acute bacterial skin and skin structure infections (ABSSSI): results from an Italian multicentre survey with expert discussion. [PDF]

JAC Antimicrob Resist
Gazzola L, Augello M, Cavinato S, Briozzo A, D'Amico F, Schiano Moriello N, Segala FV, Frallonardo L, Di Gennaro F, Saracino A, Tacconi D, Gilio M, Frontuto M, Parruti G, Cattelan A, Marchetti G.   +15 more
europepmc   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

The pivotal role of social identification in explaining authentic leadership's effect on team organizational citizenship behavior. [PDF]

PLoS One
Boyle B, Gu J, Lu CY, Cheng Z, Yang M, Mitchell RJ.   +5 more
europepmc   +1 more source

Terahertz Channel Modeling, Estimation and Localization in RIS‐Assisted Systems

Advanced Electronic Materials, EarlyView.
Reconfigurable intelligent surfaces have become a recent intensive research focus. Based on practical applications, channel strategies for RIS‐assisted terahertz wireless communication systems are categorized into three different types: channel modeling, channel estimation, and channel localization.
Hongjing Wang, Weipeng Wang, Xuan Cong, Shiyu Wang, Gao Li, Sen Gong, Lin Huang, Hongxin Zeng, Yaxin Zhang, Ziqiang Yang   +9 more
wiley   +1 more source

Taking the Next Step: How Can Implementation Science Advance Diabetes Foot Care for Rural and Remote Australians? [PDF]

J Foot Ankle Res
Byrnes A, Charles J, Cramb S, Jensen S, Johnston T, Larkins S, McPhail S, Netten JJV, Parker CN, Tulleners R, Tyack Z, Golledge J, Lazzarini PA, QFeet Study Group.   +13 more
europepmc   +1 more source