Results 191 to 200 of about 1,655,746 (410)

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

open access: yesAdvanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li   +3 more
wiley   +1 more source

TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

open access: yesAdvanced Science, EarlyView.
TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang   +8 more
wiley   +1 more source

Insights into Siglec‐7 Binding to Gangliosides: NMR Protein Assignment and the Impact of Ligand Flexibility

open access: yesAdvanced Science, EarlyView.
The molecular recognition of the sugar moiety of GD3 and Gb3 (globotriaosylceramide) derivatives by Siglec‐7 has been thoroughly studied offering insights for cancer diagnostics and therapies. A combination of structural biology techniques, nuclear magnetic resonance (NMR) spectroscopy, physicochemical analysis, and in silico methods suggested that ...
Cristina Di Carluccio   +15 more
wiley   +1 more source

International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma

open access: yesJournal of Thoracic Oncology, 2011
W. Travis   +47 more
semanticscholar   +1 more source

Synchrotron Radiation‐Based Tomography of an Entire Mouse Brain with Sub‐Micron Voxels: Augmenting Interactive Brain Atlases with Terabyte Data

open access: yesAdvanced Science, EarlyView.
Extended‐field acquisition enables sub‐micron X‐ray imaging of a full mouse brain. The 3.3‐teravoxel volume is reconstructed, registered to a reference atlas, and stored in hierarchical format to augment currently available atlases and improve resolution in the third dimension by an order of magnitude.
Mattia Humbel   +8 more
wiley   +1 more source

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