Results 41 to 50 of about 4,149,746 (288)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Aerodynamic design of high-lift devices for enhanced low-height takeoff in wing-in-ground effect craft

Applied Ocean Research
Wing-in-ground effect (WIG) craft represents a class of high-performance ship, utilizing ground effect to achieve ultra-low-height flight with an exceptional lift-to-drag ratio.
Yiheng Wang, Wenping Song, Fuyang Ding, Chengpeng Liu, Zhonghua Han, Yajun Shi   +5 more
doaj   +1 more source

Multidisciplinary Optimization of Thermal Insulation Layer for Stratospheric Airship with a Solar Array

Aerospace, 2022
Stratospheric airships with a solar array have demonstrated overwhelming superiority in many aspects, such as earth observation, meteorological survey, and communication relay. The solar array supplies sufficient power for the airship to be in flight for
Yang Liu, Ziyuan Xu, Huafei Du, Mingyun Lv   +3 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Analytical Sensitivity Analysis of Dynamic Problems with Direct Differentiation of Generalized-α Time Integration

Machines
In this paper, the direct differentiation of generalized-α time integration is derived, equations are introduced and results are shown. Although generalized-α time integration has found usage, the derivation and the resulting equations for the analytical
Erich Wehrle, Veit Gufler
doaj   +1 more source

An Integrated Design and Optimization Approach for Radial Inflow Turbines—Part II: Multidisciplinary Optimization Design

Applied Sciences, 2018
This paper proposes an integrated design and optimization approach for radial inflow turbines consisting of an automated preliminary design module and a flexible three-dimensional multidisciplinary optimization module.
Qinghua Deng, Shuai Shao, Lei Fu, Haifeng Luan, Zhenping Feng   +4 more
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

CURRICULUM OPTIMIZATION ON THE BASIS OF A MULTIDISCIPLINARY APPROACH

International scientific journal "Internauka", 2017
The aim of the study is to find ways of specialty curriculum optimization on the basis of a multidisciplinary approach. The state of the art is characterized by the lack of well-defined criteria for the synergistic integration of disciplines within the specialty curriculum, which necessitated the solution of the following issues: in relation to which ...
Sergeyeva, Tetyana, Vasylieva, Kateryna, Iamnytskyi, Stanislav   +2 more
openaire   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source