Results 91 to 100 of about 1,300,615 (222)
The Journal of Physiology, EarlyView.Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger +4 more
wiley +1 more source
Validating the antiseizure effects of vitexin and related flavone glycosides in zebrafish
Frontiers in PharmacologyCurrent epilepsy treatments often fail to provide sufficient control over seizures, highlighting the need for new therapeutic agents. Vitexin, a flavone with antioxidant, anti-inflammatory, and neuroprotective properties, was previously shown to suppress
Audrey Breckenridge +3 more
doaj +1 more source
Frontiers in Neuroscience, 2016 High-density microelectrode arrays (HDMEA) have been recently introduced to study principles of neural function at high spatial resolution. However, the exact nature of the experimentally observed extracellular action potentials (EAPs) is still ...
Kosmas Deligkaris +5 more
doaj +1 more source
Amacrine cell inputs to OFF midget ganglion cells in macaque retina
The Journal of Physiology, EarlyView.Abstract figure legend The goal of this study was to explain the findings from physiological studies that OFF midget ganglion cells had larger receptive field centers than expected from their dendritic field diameters. First, we confirmed that OFF mRGCs (OFF MGC) receive input from diffuse bipolar cells (DB) as well as OFF midget bipolar cells (FMB ...
David W. Marshak +8 more
wiley +1 more source
Journal of Neurophysiology, 2018 Neural circuits typically consist of many different types of neurons, and one faces a challenge in disentangling their individual contributions in measured neural activity.
A. Buccino +8 more
semanticscholar +1 more source
Genome engineering of a neuronal specific, optogenetic, induced pluripotent stem cell line
Stem Cell ResearchControl of neuronal activity by optogenetic tools is increasingly explored in disease modelling and optogenetics and holds great promise for regenerative therapy.
Kea Aline Schmoll +5 more
doaj +1 more source
Frontiers in Neural Circuits, 2012 Pathological high frequency oscillations (250-600Hz) are present in the brains of epileptic animals and humans. The etiology of these oscillations and how they contribute to the diseased state remains unclear.
Chadwick M Hales +6 more
doaj +1 more source
Spatial transcriptomics in epilepsy research: Early successes, opportunities, and challenges
Epilepsia, EarlyView.
Donald J. Phillips +4 more
wiley +1 more source
Glia, Volume 74, Issue 1, January 2026.Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao +9 more
wiley +1 more source
Hippocampal‐Prelimbic Coupling During Context‐Dependent Extinction Retrieval in Rats
Hippocampus, Volume 36, Issue 1, January 2026.ABSTRACT After fear conditioning, repeated presentation of the conditioned stimulus (CS) alone produces a context‐dependent extinction of learned fear. The hippocampus has a critical role in this process, but the mechanism by which contextual information encoded by the hippocampus leads to fear suppression is unknown.
Flávio Afonso Gonçalves Mourão +3 more
wiley +1 more source