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Emerging Trends in Flexible Active Multielectrode Arrays
Chemistry of Materials, 2019The spatiotemporal bioelectrical signals produced by living bodies play a significant role in enlightening biological functions. In recent years, flexible devices have emerged as a means of monitoring biological information. In order to measure bioelectrical signals using a two-dimensional flexible device, it is necessary to combine a flexible ...
Wonryung Lee, Takao Someya
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Integration of microstructured scaffolds, neurons, and multielectrode arrays
2014Recent progresses in neuroelectronics and lab-on-a-chip technologies are providing novel opportunities for neuroscience research and applications. However, the experimental performances of these novel devices are not only the result of the artificially implemented features, such as those resulting from advanced electrode materials, from electrode ...
Alessandro, Simi +4 more
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Frequency- Wavenumber Spectrum Analysis of EEG Multielectrode Array Data
IEEE Transactions on Biomedical Engineering, 1974Electroencephalographic (EEG) data consisting of visual evoked responses monitored via an array of electrodes from humans and penicillin-induced focal epileptic discharge data recorded from rat neocortex are analyzed. This procedure, previously applied to seismic array data, offers a method by which high-resolution vector velocity and, thus, direction ...
L J, Pinson, D G, Childers
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Thin-film multielectrode arrays for a cochlear prosthesis
IEEE Transactions on Electron Devices, 1982The design and fabrication of flexible thin-film microelectrode arrays for use in a cochlear prosthesis are described. The electrode array is designed to be inserted through the round window of the cochlea into the spiral scala tympani chamber of the cochlea. A lifetime of decades under stimulation is sought.
S.A. Shamma-Donoghue +4 more
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Low-stress silicon nitride for insulating multielectrode arrays
Proceedings of 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2002Discusses the use of low-stress silicon nitride for the insulation of a silicon-based multielectrode array. Tested parameters include adhesion, resistance, and biocompatibility. Adhesion of the silicon nitride to silicon test strips and resistance measurements made during accelerated life testing show favorable results. Initial biocompatibility testing
K.J. James, R.A. Normann
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Fabrication of polydimethylsiloxane (PDMS) - based multielectrode array for neural interface
2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2013Flexible multielectrode arrays (MEAs) are being developed with various materials, and polyimide has been widely used due to the conveniece of process. Polyimide is developed in the form of photoresist. And this enable precise and reproducible fabrication.
Jun-Min, Kim +4 more
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Graphene Multielectrode Arrays as a Versatile Tool for Extracellular Measurements
Advanced Healthcare Materials, 2017Graphene multielectrode arrays (GMEAs) presented in this work are used for cardio and neuronal extracellular recordings. The advantages of the graphene as a part of the multielectrode arrays are numerous: from a general flexibility and biocompatibility to the unique electronic properties of graphene. The devices used for extensive in vitro studies of a
Dmitry Kireev +5 more
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Response calibration in neuroblastoma cultures over multielectrode array
Neurocomputing, 2012Multielectrode Array (MEA) setups have been designed for direct culturing neural cells over silicon or glass substrates, providing the capability to stimulate and record simultaneously populations of neural cells. Neuroblastoma cultures over MEA have a very low signal/noise ratio response to stimulation, so it is difficult to detect small changes in ...
J.M. Cuadra +6 more
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Electrophysiological Mapping of Cat Primary Auditory Cortex with Multielectrode Arrays
Annals of Biomedical Engineering, 2006The present study employs simultaneous multielectrode recording techniques to study the feline primary auditory cortex (AI) to characterize its functional architecture. High electrode-count microelectrode arrays provide a high spatial and temporal view of AI, but at the potential cost of significant cortical insult.
Seung-Jae, Kim +3 more
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Studying mammalian neurons in vitro with multielectrode arrays
Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439), 2004The basic principles for recording and stimulation with extracellular electrodes are described, and how they relate to the use of multielectrode arrays, MEAs, for studies of neural networks in culture. The main engineering issues for building arrays are described, and some examples are given of their use. The "neurochip" which has evolved from standard
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