Results 61 to 70 of about 1,291,062 (187)

β-amyloid’s neurotoxic mechanisms as defined by in vitro microelectrode arrays: a review

Pharmacological Research
Alzheimer's disease is characterized by the aggregation of β-amyloid, a pathological feature believed to drive the neuronal loss and cognitive decline commonly seen in the disease.
Aoife O’Connell, Leo Quinlan, Andrea Kwakowsky   +2 more
doaj   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

autoMEA: machine learning-based burst detection for multi-electrode array datasets

Frontiers in Neuroscience
Neuronal activity in the highly organized networks of the central nervous system is the vital basis for various functional processes, such as perception, motor control, and cognition. Understanding interneuronal connectivity and how activity is regulated
Vinicius Hernandes, Anouk M. Heuvelmans, Anouk M. Heuvelmans, Valentina Gualtieri, Dimphna H. Meijer, Geeske M. van Woerden, Geeske M. van Woerden, Geeske M. van Woerden, Eliska Greplova   +8 more
doaj   +1 more source

Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons in vitro

Frontiers in Synaptic Neuroscience, 2021
Perineuronal nets (PNNs) are specialized, reticular structures of the extracellular matrix (ECM) that can be found covering the soma and proximal dendrites of a neuronal subpopulation.
David Wegrzyn, Nadja Freund, Andreas Faissner, Georg Juckel   +3 more
doaj   +1 more source

Combining biophysical modeling and deep learning for multielectrode array neuron localization and classification.

Journal of Neurophysiology, 2018
Neural circuits typically consist of many different types of neurons, and one faces a challenge in disentangling their individual contributions in measured neural activity.
A. Buccino, M. Kordovan, T. V. Ness, Benjamin Merkt, P. Häfliger, M. Fyhn, G. Cauwenberghs, S. Rotter, G. Einevoll   +8 more
semanticscholar   +1 more source

Biotechnical Multiscale Engineering of Scaffolds for Stem Cell and Organoid Research

Small, EarlyView.
Biotechnical multiscale engineering consideration of geometric and structural parameters, which is called biotechnical multiscale engineering, has an influence on stem cell development and organogenesis comparable to that of molecular genetics and biochemical parameters.
Merle‐Johanna Küstner, Christian Marx, Peter beim Graben, Serafim Rodrigues, Jörg Hampl, Frank Weise, Michael Gebinoga, Leon Kaysan, Maren Klett, Dana Brauer, Gregor Schlingloff, Doris Heinrich, Insa Sigrid Schroeder, Andreas Schober   +13 more
wiley   +1 more source

Role of Connexin Channels in the Retinal Light Response of a Diurnal Rodent

Frontiers in Cellular Neuroscience, 2014
Several studies have shown that connexin channels play an important role in retinal neural coding in nocturnal rodents. However, the contribution of these channels to signal processing in the retina of diurnal rodents remains unclear.
Angelina ePalacios-Munoz, Maria Jose eEscobar, Alex eVielma, Joaquin eAraya, Aland eAstudillo, Isaac eGarcia, Gonzalo eValdivia, Jose eHurtado, Jose eHurtado, Oliver eSchmachtenberg, Agustin Demetrio Martinez, Adrian G Palacios, Adrian G Palacios   +12 more
doaj   +1 more source

Multi‐Channel Neural Interface for Neural Recording and Neuromodulation

Small Methods, EarlyView.
This review highlights recent advances in multi‐channel neural interface technologies, covering both high‐resolution electrophysiological recording systems and multifunctional platforms with integrated capabilities. It also discusses innovations in structure and materials for reduced invasiveness, state‐of‐the‐art data analysis, including machine ...
Eunmin Kim, Won Gi Chung, Enji Kim, Myoungjae Oh, Joonho Paek, Taekyeong Lee, Dayeon Kim, Seung Hyun An, Sumin Kim, Jang‐Ung Park   +9 more
wiley   +1 more source

Maximum Entropy Approaches to Living Neural Networks

Entropy, 2010
Understanding how ensembles of neurons collectively interact will be a key step in developing a mechanistic theory of cognitive processes. Recent progress in multineuron recording and analysis techniques has generated tremendous excitement over the ...
John M. Beggs, Alan Litke, Alexander Sher, Wladyslaw Dabrowski, Pawel Hottowy, Jon P. Hobbs, Fang-Chin Yeh, Aonan Tang   +7 more
doaj   +1 more source

Comparison of Cerebral Micro‐Embolization Detected by Transcranial Doppler Examination Between Radiofrequency Ablation and Pulsed Field Ablation for Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, EarlyView.
Transcranial doppler monitoring of microembolic signals during atrial fibrillation ablation. ABSTRACT Background and Aims Pulsed Field Ablation (PFA) can establish pulmonary vein isolation via irreversible electroporation and is believed to reduce overall complications; however, periprocedural stroke has also been reported after PFA procedures ...
Tobias Schreiber, Regina von Rennenberg, Tim Bastian Brämswig, Ulf Landmesser, Gerhard Hindricks, Patrick Nagel, Verena Tscholl, Martin Huemer, Johannes Lucas, Philipp Attanasio, Christian H. Nolte   +10 more
wiley   +1 more source