Results 71 to 80 of about 1,291,062 (187)

Flexible Multi-Electrode Array for Medical Applications

Acta Polytechnica, 2012
A flexible multi-electrode array (MEA) with an embedded silicon chip for electrical stimulation of neurons or for recording action potentials has been manufactured and characterized.
Nadine Winkin, Wilfried Mokwa
doaj  

Corrosion Localization Analysis in T-Shape Pipe Junction Based on Multielectrode Current Measurements

Advances in Materials Science and Engineering, 2020
The water flow rate and galvanic current distribution in the T-shape junction of steel pipes were investigated using the multielectrode array approach. The inner surface of polypropylene pipes junction was divided into 15 separate sections, and a steel ...
Georgii S. Vasyliev
doaj   +1 more source

Baclofen-associated neurophysiologic target engagement across species in fragile X syndrome

Journal of Neurodevelopmental Disorders, 2022
Background Fragile X syndrome (FXS) is the most common inherited form of neurodevelopmental disability. It is often characterized, especially in males, by intellectual disability, anxiety, repetitive behavior, social communication deficits, delayed ...
Carrie R. Jonak, Ernest V. Pedapati, Lauren M. Schmitt, Samantha A. Assad, Manbir S. Sandhu, Lisa DeStefano, Lauren Ethridge, Khaleel A. Razak, John A. Sweeney, Devin K. Binder, Craig A. Erickson   +10 more
doaj   +1 more source

Overcoming the Challenges of Transmural Durable Lesions With PFA—Impact of Electrode Design and Contact Assessment

Pacing and Clinical Electrophysiology, EarlyView.
Abstract Electrode design and reliable contact assessment are critical for creating durable pulsed field ablation (PFA) lesions to treat atrial fibrillation while minimizing collateral damage. This review introduces a novel “map‐and‐ablate” PFA catheter featuring flat electrodes, thermal contact assessment, and fully customizable electrode selection ...
Lea Melki, Saar Moisa, Dan Reinders, Samantha Boucher   +3 more
wiley   +1 more source

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger, Verena Charwat, Kevin E. Healy, Samuel Wall, Aslak Tveito   +4 more
wiley   +1 more source

Revealing Neuronal Function through Microelectrode Array Recordings

Frontiers in Neuroscience, 2015
Microelectrode arrays and microprobes have been widely utilized to measure neuronal activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate neurons at multiple sites simultaneously. However, unlike the single-cell
Marie Engelene J Obien, Kosmas eDeligkaris, Kosmas eDeligkaris, Torsten eBullmann, Douglas J Bakkum, Urs eFrey, Urs eFrey, Urs eFrey   +7 more
doaj   +1 more source

Amacrine cell inputs to OFF midget ganglion cells in macaque retina

The Journal of Physiology, EarlyView.
Abstract figure legend The goal of this study was to explain the findings from physiological studies that OFF midget ganglion cells had larger receptive field centers than expected from their dendritic field diameters. First, we confirmed that OFF mRGCs (OFF MGC) receive input from diffuse bipolar cells (DB) as well as OFF midget bipolar cells (FMB ...
David W. Marshak, Andrea S. Bordt, Emma R. Yang, Joel N. Yearick, Marcus Mazzaferri, James A. Kuchenbecker, Judith Mosinger Ogilvie, Sara S. Patterson, Jay Neitz   +8 more
wiley   +1 more source

Validating the antiseizure effects of vitexin and related flavone glycosides in zebrafish

Frontiers in Pharmacology
Current epilepsy treatments often fail to provide sufficient control over seizures, highlighting the need for new therapeutic agents. Vitexin, a flavone with antioxidant, anti-inflammatory, and neuroprotective properties, was previously shown to suppress
Audrey Breckenridge, Sanskriti Basnyat, Eva Fitch, Colleen Carpenter-Swanson   +3 more
doaj   +1 more source

Extracellularly Recorded Somatic and Neuritic Signal Shapes and Classification Algorithms for High-Density Microelectrode Array Electrophysiology

Frontiers in Neuroscience, 2016
High-density microelectrode arrays (HDMEA) have been recently introduced to study principles of neural function at high spatial resolution. However, the exact nature of the experimentally observed extracellular action potentials (EAPs) is still ...
Kosmas Deligkaris, Kosmas Deligkaris, Torsten Bullmann, Urs Frey, Urs Frey, Urs Frey   +5 more
doaj   +1 more source

Altered Inflammatory Signature in a C9ORF72 ‐ALS iPSC‐Derived Motor Neuron and Microglia Coculture Model

Glia, Volume 74, Issue 1, January 2026.
Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao, Jessica L. Brothwood, Harpreet Saini, Gregory A. O'Sullivan, Carla F. Bento, James M. McCarthy, Nicola G. Wallis, Elena Di Daniel, Brent Graham, Daniel M. Tams   +9 more
wiley   +1 more source