Results 81 to 90 of about 1,291,062 (187)

Decreased RYR2 Cluster Size and Abnormal SR Ca2+ Release Contribute to Arrhythmogenesis in TMEM43‐Related ARVC

Advanced Science, Volume 12, Issue 45, December 4, 2025.
The TMEM43 ‐ P386S mutation causes arrhythmogenic right ventricular cardiomyopathy (ARVC) by mislocalizing itself from nuclear envelope (NE) to cytoplasm, disrupting lamin B2 (a novel TMEM43 interactor) localization, NE integrity and chromatin accessibility, causing hyper ‐ phosphorylation and reduced expression/clustering of ryanodine receptor type 2 (
Jiaxi Shen, Xiaochen Wang, Hangping Fan, Yaxun Sun, Tingyu Gong, Hangyuan Qiu, Jue Wang, Ziwei Pan, Yanna Dang, Hongkun Wang, Danni Zhou, Tianyi Zhu, Hao Wang, Xianzhen Chen, Lizhen Xu, Jun Su, Fan Yang, Yiquan Tang, Xuguang Li, Bing Yang, Lenan Zhuang, Wei Wang, Chenyang Jiang, Ping Liang   +23 more
wiley   +1 more source

Genome engineering of a neuronal specific, optogenetic, induced pluripotent stem cell line

Stem Cell Research
Control of neuronal activity by optogenetic tools is increasingly explored in disease modelling and optogenetics and holds great promise for regenerative therapy.
Kea Aline Schmoll, Thomas Mager, Timothy Pok-man Tse, Ahmed Alameldeen, Wolfram-Hubertus Zimmermann, Maria-Patapia Zafeiriou   +5 more
doaj   +1 more source

Fouling in Emulsion Polymerization: Fundamentals and Methods of Investigation

Journal of Applied Polymer Science, Volume 142, Issue 43, November 15, 2025.
ABSTRACT The current understanding of fouling in emulsion polymerization is summarized from an engineering perspective and from a physical‐chemistry perspective. Emulsion polymerization in semibatch mode offers better control over the number of particles and side reactions than batch mode. Both reaction fouling and particulate fouling are observed, the
Holly A. Huellemeier, Kevin M. Hoffmann, Olinda Sidorow, Stephan Scholl, Wolfgang Augustin, Diethelm Johannsmann   +5 more
wiley   +1 more source

Stimulus induced high frequency oscillations are present in neuronal networks on microelectrode arrays.

Frontiers in Neural Circuits, 2012
Pathological high frequency oscillations (250-600Hz) are present in the brains of epileptic animals and humans. The etiology of these oscillations and how they contribute to the diseased state remains unclear.
Chadwick M Hales, Chadwick M Hales, Riley eZeller-Townson, Jonathan P Newman, James T Shoemaker, Nathan J Killian, Steve M Potter   +6 more
doaj   +1 more source

Towards High‐Acuity Vision Restoration: Hybrid Retinal Prosthesis Composed of a High‐Density Multielectrode Array Integrated With Glutamatergic Cells

Advanced Functional Materials, Volume 35, Issue 45, November 5, 2025.
This work introduces a novel Hybrid Retinal Implant (HRI), composed of a high‐density electrode array integrated with glutamatergic neurons to overcome key limitations of current retinal prostheses. The significant reduction of activation threshold and of electrode cross‐talk yields in an improved spatial resolution.
Nairouz Farah, Amos Markus, Gal Shpun, Yoav Chemla, Erel Lasnoy, Tamar Azrad‐Leibovitch, Fikre Fentahon, Zeev Zalvesky, Yossi Mandel   +8 more
wiley   +1 more source

Vertical Nanostructures as Novel Interfaces for Brain Research

Advanced Materials Interfaces, Volume 12, Issue 21, November 10, 2025.
This review highlights the unique features of vertical nanostructures (nanoneedles, nanostraws, nanopillars, and nanowires) for applications in brain research. Various characteristics of nanostructures, including material selection, fabrication methodology, and geometric designs, are discussed for their specific use in neurite guidance, neuron pinning,
Hao Nguyen Tran, Andrea J. O'Connor, Chennupati Jagadish, Vini Gautam   +3 more
wiley   +1 more source

Improving Kv7 targeting anticonvulsants ‐ will repurposing save the day?

British Journal of Pharmacology, EarlyView.
Nikita Gamper
wiley   +1 more source

Iontronic Regulation of Nanoconfined Electrical Double Layers on Dielectric Solids

Small Science, Volume 5, Issue 11, November 2025.
In this review, the evolution from classical EDL models at conductor‐liquid interfaces to extended frameworks for nonconductor‐liquid systems is revisited. Building upon this foundation, the implemented energy and information technologies are systematically classified based on the dynamic regulation strategies of different EDL substructures ...
Xiang Li, Yu Wei, Zhong Lin Wang, Di Wei
wiley   +1 more source

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

British Journal of Pharmacology, Volume 182, Issue 22, Page 5574-5595, November 2025.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela   +16 more
wiley   +1 more source

Obtaining Multi-electrode Array Recordings from Human Induced Pluripotent Stem Cell–Derived Neurons

Bio-Protocol, 2017
Neuronal electrical properties are often aberrant in neurological disorders. Human induced pluripotent stem cells (hiPSCs)-derived neurons represent a useful platform for neurological disease modeling, drug discovery and toxicity screening in vitro ...
Xiaohong Xu, Carola Radulescu, Kagistia Utami, Mahmoud Pouladi   +3 more
doaj   +1 more source