Results 101 to 110 of about 5,192,460 (208)

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

An Integrated Metabolomics and Bioactivity Approach to Characterize Salvia heldreichiana and Salvia tomentosa Extracts

ChemistryOpen, Volume 15, Issue 10, October 2026.
S. heldreichiana and S. tomentosa can be considered as effective sources of natural bioactive agents for further in vivo pharmacological evaluation and development. The genus Salvia, widely known as sage, represents the largest group within the Lamiaceae family and includes numerous species with traditional uses.
Gokhan Zengin, Nilofar Nilofar, Alina Kalyniukova, Vasil Andruch, Giancarlo Angeles Flores, Paola Angelini, Roberto Venanzoni, Kubra Aslan, Ilhami Gulcin, Evren Yildiztugay   +9 more
wiley   +1 more source

Dietary multi-enzyme complex improves In Vitro nutrient digestibility and hind gut microbial fermentation of pigs.

PLoS ONE, 2019
This study was conducted in two stages to investigate the potential of multi-enzyme supplementation on the nutrient digestibility, growth performance, and gut microbial composition of pigs. In stage 1, effects of multi-enzyme complex (xylanase, α-amylase,
Neeraja Recharla, Duwan Kim, Sivasubramanian Ramani, Minho Song, Juncheol Park, Balamuralikrishnan Balasubramanian, Pradeep Puligundla, Sungkwon Park   +7 more
doaj   +1 more source

Engineering Photothermal Nanoplatforms for Multimodal Theranostics and Biosensing

Rare Metals, Volume 45, Issue 10, October 2026.
ABSTRACT Photothermal platforms bridge materials science and biomedicine, emerging as a transformative frontier in biomedical applications. They offer spatiotemporally precise, noninvasive modalities with cell‐type‐independent efficacy for treating a range of diseases.
Xiao Han, Peng Jin, Haiqing Wang, Hao Xue   +3 more
wiley   +1 more source

PmWRKY‐10 Enhances Pine Wilt Disease Resistance by Promoting Pinosylvin Monomethyl Ether Biosynthesis Through Transcriptional Activation of PmPMT2‐1

Molecular Plant Pathology, Volume 27, Issue 10, October 2026.
We identified a PmWRKY‐10→PmPMT2‐1→PME defence pathway in Pinus massoniana against pine wilt disease. PmWRKY‐10 activates PmPMT2‐1 to promote the accumulation of the nematicidal metabolite PME. This discovery reveals the mechanism of stilbene‐mediated resistance and provides key genetic targets for forest management.
Ziyan Nie, Shan Hu, Bin Liu, Qinghua Liu, Hengfu Yin, Zhichun Zhou, Kai Gao   +6 more
wiley   +1 more source

Next‐Generation Manufacturing: The Evolving Role of Biocatalysis in AstraZeneca

ChemBioChem, Volume 27, Issue 17, 14 September 2026.
Biocatalysis is strengthening AstraZeneca's manufacture of active pharmaceutical ingredients through faster development, robust scale‐up, and lower environmental impact. Case studies illustrate where biocatalysis delivers greatest value, while enabling platforms, teams, and partnerships shape its next phase.
Alba Diaz‐Rodriguez, Martin A. Hayes, Keith R. Mulholland, Fernando Tur, Samantha Staniland   +4 more
wiley   +1 more source

Covalent Insertion of a Mn(Salen) Type Complex in Cross‐Linked Protein Crystals: Design of an Enantioselective Artificial Epoxidase

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
An Artificial metalloenzyme was designed by a Michael addition between a MnSalen complex and a cysteine residue within NikA crystals. The heterogeneous catalyst was found capable of an enantioselective and stereospecific epoxidation of cis‐β‐methylstyrene in cristallo.
Manel Boukhallat, Ismail Benhamed, Jade Arnone, Stann Van Baaren, Clara Rinaldi, Patrice Catty, Caroline Marchi‐Delapierre, Christine Cavazza, Stéphane Ménage   +8 more
wiley   +1 more source

Efficient Production of L-Threonine by E. coli Using High-Throughput Screening and Multi-Enzyme Complex Engineering

Fermentation
To enhance the L-threonine synthesis level in Escherichia coli, this study constructed screening markers rich in L-threonine rare codons. By replacing all the threonine codons in the protein sequences with a high proportion of threonine with L-threonine ...
Chuanzhuang Guo, Nan Li, Lu Yang, Jianbin Wang, Junlin Li, Piwu Li, Junqing Wang, Ruiming Wang   +7 more
doaj   +1 more source

Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction. [PDF]

Proc Natl Acad Sci U S A, 2020
Schupfner M, Straub K, Busch F, Merkl R, Sterner R.   +4 more
europepmc   +1 more source

Data-Driven Evolutionary Design of Multienzyme-like Nanozymes

Multienzyme-like nanozymes are nanomaterials with multiple enzyme-like activities and are the focus of nanozyme research owing to their ability to facilitate cascaded reactions, leverage synergistic effects, and exhibit environmentally responsive ...
Ning Sui (2373151), Zibei Chen (18113751), Yujie Jiang (2991267), Zhiling Zhu (3116931)   +3 more
core   +2 more sources