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DNA-directed assembly of artificial multienzyme complexes
Biochemical and Biophysical Research Communications, 2008This study aims to establish model systems for the exploration of proximity effects, occurring in natural multienzyme complexes. DNA-directed assembly of covalent conjugates of DNA oligonucleotides and Glucose Oxidase (GOX) or Horseradish peroxidase (HRP) was used to generate supramolecular complexes, in which the two enzymes were arranged with defined
Joachim, Müller, Christof M, Niemeyer
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1970
Publisher Summary This chapter discusses certain features of a few well-documented examples of multienzyme complexes. The multienzyme complexes that have been most thoroughly described are composed of two to six functionally related enzymes and have molecular weights ranging from a few hundred thousand to a few million. The particles contain definite
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Publisher Summary This chapter discusses certain features of a few well-documented examples of multienzyme complexes. The multienzyme complexes that have been most thoroughly described are composed of two to six functionally related enzymes and have molecular weights ranging from a few hundred thousand to a few million. The particles contain definite
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Facilitation of Enzyme Catalysis by Formation of Multienzyme Complexes
1982There has been considerable discussion whether enzymes, generally identified as constituent of ‘soluble cellular fraction’, may be organized into multienzyme complexes.1,2 Much attention has been paid to the possibility of complex formation between enzymes which catalyze successive reactions in the same metabolic pathway3-6.
SALERNO, Costantino, P. Fasella
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[Symmetry of multienzyme complexes].
Molekuliarnaia biologiia, 1986A model for studying the symmetry of stable states arising from polyenzymic complex conformations is proposed. A formal scheme of submolecular structure self-assembly, on which the model is based, enables it not only to limit the class of conformations but in some cases to determine the structure of a complex in an unambigous manner. The model is shown
B N, Gol'dshteĭn +2 more
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Multienzyme Complex in Fatty Acid Biosynthesis
2023Fatty acid biosynthesis is a fundamental process that occurs in all living organisms and involves multiple reaction steps. Thus, a systematic transfer of the intermediates between the different catalytic sites is highly required for the efficient regulation of a pathway as well as for sustaining growth.
Pranesha Prabhakaran +4 more
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The role of multienzyme complexes in integration of cellular metabolism
Journal of Theoretical Biology, 1986The notion of the "primary block" of cellular metabolism designated as "metabolic system" is introduced. Metabolic system is defined as a metabolic pathway which corresponds to the structurally ordered multienzyme complex. The complex of glycolytic enzymes which catalyzes the anaerobic reduction of glucose-6-phosphate with production of ATP may serve ...
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A multienzyme complex for CO2 fixation.
Biochemistry, 1975Acetyl-coenzyme A carboxylase from Euglena gracilis strain Z was isolated as a component of a multienzyme complex which includes phosphoenolpyruvate carboxylase and malate dehydrogenase. The multienzyme complex was shown to exist in crude extracts and was purified to a homogeneous protein with a molecular weight of 360,000 by gel filtration.
J S, Wolpert, M L, Ernst-Fonberg
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A possible origin of RNA catalysis in multienzyme complexes
Origins of life and evolution of the biosphere, 1989Numerous attempts have recently been made to ascribe a preeminent role to RNA enzymes in primitive life systems. A model is proposed in which coenzyme-dependent RNA enzymes were initially organized in multienzyme complexes featuring (1) the continuous attachment of substrates to CoA-like carriers, as in fatty acid synthesis; and (2) the ordering of RNA
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Evidence supporting multienzyme complexes as metabolons: A review
International Journal of Biological MacromoleculesFungi are widespread organisms with complex multienzyme systems crucial for diverse biochemical processes. This study systematically reviewed research on multienzyme complexes, focusing on their isolation and identification, while examining their potential classification as metabolons.
Hebah, Al-Tamimi +4 more
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Tryptophan synthase: A multienzyme complex with an intramolecular tunnel
The Chemical Record, 2001AbstractTryptophan synthase is a classic enzyme that channels a metabolic intermediate, indole. The crystal structure of the tryptophan synthase α2β2 complex from Salmonella typhimurium revealed for the first time the architecture of a multienzyme complex and the presence of an intramolecular tunnel. This remarkable hydrophobic tunnel provides a likely
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