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Multienzyme assembly of a p53 transcription complex
Nature Structural & Molecular Biology, 2007Proline isomerization of the p53 transactivation domain has a central role in coordinating kinase signaling pathways that assemble the core p53 transcription complex.
Ted R Hupp, Malcolm Walkinshaw
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Biomimetic Multienzyme Complexes Based on Nanoscale Platforms
AIChE Journal, 2012SignificanceInspired by the widely present multienzyme complexes in nature that enable highly cooperative catalytic mechanisms, we designed a biomimetic dual‐functionalized nanoparticle‐based platform for colocalizing multiple enzymes. The use of nanoscale materials together with a novel sequential colocalization approach with two model enzymes ...
Feng Jia +2 more
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Lysosomal multienzyme complex: Biochemistry, genetics, and molecular pathophysiology
2001Lysosomal enzymes sialidase (alpha-neuraminidase), beta-galactosidase, and N-acetylaminogalacto-6-sulfate sulfatase are involved in the catabolism of glycolipids, glycoproteins, and oligosaccharides. Their functional activity in the cell depends on their association in a multienzyme complex with lysosomal carboxypeptidase, cathepsin A.
A V, Pshezhetsky, M, Ashmarina
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A Multienzyme Complex for De Novo Purine Biosynthesis
1977Multienzyme complexes are defined as aggregates of different functionally related enzymes integrated into highly organized structures by non-covalent bonds. Such a structural arrangement is considered to confer a catalytic advantage in that an unstable intermediate may be transferred more efficiently from one active site to the next.
P B, Rowe +3 more
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[Structure-activity relationships in multienzyme complexes].
Molekuliarnaia biologiia, 1996Structures and molecular kinetic models of function of 2-oxo acid dehydrogenase complexes were analyzed. It was suggested that identical protein subunits in the multienzyme complexes as in the structure capable of self-assembly have identical contacts with the neighbors and identical environment.
B N, Gol'dshteĭn +2 more
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Evidence supporting multienzyme complexes as metabolons: A review
International Journal of Biological MacromoleculesFungi are widespread organisms with complex multienzyme systems crucial for diverse biochemical processes. This study systematically reviewed research on multienzyme complexes, focusing on their isolation and identification, while examining their potential classification as metabolons.
Hebah, Al-Tamimi +4 more
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A multienzyme complex for CO2 fixation.
Biochemistry, 1975Acetyl-coenzyme A carboxylase from Euglena gracilis strain Z was isolated as a component of a multienzyme complex which includes phosphoenolpyruvate carboxylase and malate dehydrogenase. The multienzyme complex was shown to exist in crude extracts and was purified to a homogeneous protein with a molecular weight of 360,000 by gel filtration.
J S, Wolpert, M L, Ernst-Fonberg
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Multienzyme Complex Reassembles Itself
Chemical & Engineering News Archive, 1964openaire +1 more source