Results 241 to 250 of about 6,604,045 (304)
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The pyruvate dehydrogenase multienzyme complex
Current Opinion in Structural Biology, 1992Abstract During the review period, several structures of component enzymes and domains of enzymes of this multienzyme complex were determined. Three structures of the flavoprotein component, dihydrolipoamide dehydrogenase, became available. The structure of the core component, dihydrolipoyl acetyltransferase, can in principle be constructed from the ...
Richard N. Perham +2 more
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Multienzyme complexes in DNA precursor biosynthesis
Advances in Enzyme Regulation, 1979Abstract Several features of DNA replication suggest the involvement of multienzyme complexes in deoxyribonucleotide biosynthesis. Such complexes could generate intracellular concentration gradients of DNA precursors, with high levels being maintained at their sites of utilization, namely, replication forks.
Thomas W. North +2 more
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Regulation of the Pyruvate Dehydrogenase Multienzyme Complex
Annual Review of Nutrition, 1993To maximize catalytic efficiency in metabolic pathways of both prokaryotic and eUkaryotic cells, enzymatic components are occasionally clustered or complexed physically. Organization of multiple catalytic functions into a single enzyme complex can be accomplished in two ways.
Denis B. Buxton +3 more
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[41] Purification of multienzyme complexes
1990Publisher Summary This chapter discusses the use of enzymes of nucleotide metabolism to illustrate procedures for the purification and characterization or multi-enzyme complexes. A significant result of these procedures is the successful use of ammonium sulfate precipitation to concentrate and enrich each of the three complexes.
Christopher K. Mathews, Paul A. Srere
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DNA-directed assembly of artificial multienzyme complexes
Biochemical and Biophysical Research Communications, 2008This study aims to establish model systems for the exploration of proximity effects, occurring in natural multienzyme complexes. DNA-directed assembly of covalent conjugates of DNA oligonucleotides and Glucose Oxidase (GOX) or Horseradish peroxidase (HRP) was used to generate supramolecular complexes, in which the two enzymes were arranged with defined
Joachim Müller, Christof M. Niemeyer
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The Pyruvate Dehydrogenase Multienzyme Complex
Angewandte Chemie International Edition in English, 1975AbstractThe three enzymes pyruvate dehydrogenase, dihydrolipoamide transacetylase, and dihydrolipoamide dehydrogenase constitute the pyruvate dehydrogenase multienzyme complex of E. coli; in mammals the complex also contains a kinase and a phosphatase.
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Journal of Agricultural and Food Chemistry, 2017
Metabolic channeling enables efficient transfer of the intermediates by forming a multienzyme complex. To leverage the metabolic channeling for improved biosynthesis, we coexpressed N-acetylneuraminic acid lyase from C.
Zhenfu Wang +6 more
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Metabolic channeling enables efficient transfer of the intermediates by forming a multienzyme complex. To leverage the metabolic channeling for improved biosynthesis, we coexpressed N-acetylneuraminic acid lyase from C.
Zhenfu Wang +6 more
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1970
Publisher Summary This chapter discusses certain features of a few well-documented examples of multienzyme complexes. The multienzyme complexes that have been most thoroughly described are composed of two to six functionally related enzymes and have molecular weights ranging from a few hundred thousand to a few million. The particles contain definite
David J. Cox, Lester J. Reed
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Publisher Summary This chapter discusses certain features of a few well-documented examples of multienzyme complexes. The multienzyme complexes that have been most thoroughly described are composed of two to six functionally related enzymes and have molecular weights ranging from a few hundred thousand to a few million. The particles contain definite
David J. Cox, Lester J. Reed
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Small, 2022
Most nanozymes in development for medical applications only exhibit single-enzyme-like activity, and are thus limited by insufficient catalytic activity and dysfunctionality in complex pathological microenvironments.
Dan Li +4 more
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Most nanozymes in development for medical applications only exhibit single-enzyme-like activity, and are thus limited by insufficient catalytic activity and dysfunctionality in complex pathological microenvironments.
Dan Li +4 more
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Facilitation of Enzyme Catalysis by Formation of Multienzyme Complexes
1982There has been considerable discussion whether enzymes, generally identified as constituent of ‘soluble cellular fraction’, may be organized into multienzyme complexes.1,2 Much attention has been paid to the possibility of complex formation between enzymes which catalyze successive reactions in the same metabolic pathway3-6.
SALERNO, Costantino, P. Fasella
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